[HTML][HTML] Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …
[HTML][HTML] Photoreceptor metabolic reprogramming: current understanding and therapeutic implications
WW Pan, TJ Wubben, CG Besirli - Communications biology, 2021 - nature.com
Acquired and inherited retinal disorders are responsible for vision loss in an increasing
proportion of individuals worldwide. Photoreceptor (PR) death is central to the vision loss …
proportion of individuals worldwide. Photoreceptor (PR) death is central to the vision loss …
Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy
T Bosanac, RO Hughes, T Engber, R Devraj… - Brain, 2021 - academic.oup.com
Axonal degeneration is an early and ongoing event that causes disability and disease
progression in many neurodegenerative disorders of the peripheral and central nervous …
progression in many neurodegenerative disorders of the peripheral and central nervous …
Structural basis for SARM1 inhibition and activation under energetic stress
M Sporny, J Guez-Haddad, T Khazma, A Yaron… - Elife, 2020 - elifesciences.org
SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key
cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its …
cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its …
[HTML][HTML] Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
AJ Bloom, X Mao, A Strickland, Y Sasaki… - Molecular …, 2022 - Springer
Background In response to injury, neurons activate a program of organized axon self-
destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is …
destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is …
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in
patients with ALS and other motor nerve Page 1 Gilley et al. eLife 2021;10:e70905. DOI …
patients with ALS and other motor nerve Page 1 Gilley et al. eLife 2021;10:e70905. DOI …
Live imaging reveals the cellular events downstream of SARM1 activation
SARM1 is an inducible NAD+ hydrolase that triggers axon loss and neuronal cell death in
the injured and diseased nervous system. While SARM1 activation and enzyme function are …
the injured and diseased nervous system. While SARM1 activation and enzyme function are …
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
Leber congenital amaurosis type nine is an autosomal recessive retinopathy caused by
mutations of the NAD+ synthesis enzyme NMNAT1. Despite the ubiquitous expression of …
mutations of the NAD+ synthesis enzyme NMNAT1. Despite the ubiquitous expression of …
Probing organoid metabolism using Fluorescence Lifetime Imaging Microscopy (FLIM): The next frontier of drug discovery and disease understanding
Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …
SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration
Axonal degeneration contributes to the pathogenesis of many neurodegenerative disorders,
motivating efforts to dissect the mechanism of pathological axon loss in order to develop …
motivating efforts to dissect the mechanism of pathological axon loss in order to develop …