Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

Protein and phosphoinositide kinases have been successfully exploited as drug targets in
various disease areas, principally in oncology. In malaria, several protein kinases are under …

Malaria parasite release (egress) from host red blood cells involves parasite-mediated
membrane poration and rupture, thought to involve membrane-lytic effector molecules such …

Calcium signaling regulated by the cGMP-dependent protein kinase (PKG) controls key life
cycle transitions in the malaria parasite. However, how calcium is mobilized from …

All intracellular pathogens must escape (egress) from the confines of their host cell to
disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole …

An essential step in the life cycle of malaria parasites is their egress from hepatocytes, which
enables the transition from the asymptomatic liver stage to the pathogenic blood stage of …

ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and
transmission control measures led to a decrease in the global malaria burden over the …

The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+
homeostasis in malaria parasites and has been implicated in the mechanism of action of …

Recent progress in genomics and molecular genetics has empowered novel approaches to
study gene functions in disease-causing pathogens. In the human malaria parasite …

During the course of the asexual erythrocytic stage of development, Plasmodium spp.
parasites undergo a series of morphological changes and induce alterations in the host cell …