[HTML][HTML] Crk and CrkL as therapeutic targets for cancer treatment
T Park - Cells, 2021 - mdpi.com
Crk and CrkL are cellular counterparts of the viral oncoprotein v-Crk. Crk and CrkL are
overexpressed in many types of human cancer, correlating with poor prognosis …
overexpressed in many types of human cancer, correlating with poor prognosis …
[HTML][HTML] Fetal nuchal edema and developmental anomalies caused by gene mutations in mice
A Sugiyama, M Hirashima - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Fetal nuchal edema, a subcutaneous accumulation of extracellular fluid in the fetal neck, is
detected as increased nuchal translucency (NT) by ultrasonography in the first trimester of …
detected as increased nuchal translucency (NT) by ultrasonography in the first trimester of …
Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development
Background Endocardial cells are a major progenitor population that gives rise to heart
valves through endocardial cushion formation by endocardial to mesenchymal …
valves through endocardial cushion formation by endocardial to mesenchymal …
Downregulation of a CT10 regulator of kinase (Crk) promotes the formation of diapause embryos in the brine shrimp Artemia
ZJ Yan, WT Wu, LY Xu, N Bi, F Yang, WJ Yang… - Gene, 2023 - Elsevier
To survive under harsh environments, embryonic development of Artemia was arrested at
the gastrula stage and released as the diapause embryo. Cell cycle and metabolism were …
the gastrula stage and released as the diapause embryo. Cell cycle and metabolism were …
Cell shape‐based chemical screening reveals an epigenetic network mediated by focal adhesions
T Kanazawa, H Michida, Y Uchino, A Ishihara… - The FEBS …, 2021 - Wiley Online Library
Adapter proteins CRK and CRKL participate in a variety of signaling pathways, including cell
adhesion, and fate regulation of mammalian cells. However, the molecular functions of …
adhesion, and fate regulation of mammalian cells. However, the molecular functions of …
Crk/Crkl regulates early angiogenesis in mouse embryos by accelerating endothelial cell maturation
Rationale: Ubiquitously expressed cytoplasmic adaptors CRK and CRKL mediate multiple
signaling pathways in mammalian embryogenesis. They are also associated with …
signaling pathways in mammalian embryogenesis. They are also associated with …
Crk and Crkl have shared functions in neural crest cells for cardiac outflow tract septation and vascular smooth muscle differentiation
CRK and CRKL encode cytoplasmic adaptors that contribute to the etiology of congenital
heart disease. Neural crest cells (NCCs) are required for cardiac outflow tract (OFT) …
heart disease. Neural crest cells (NCCs) are required for cardiac outflow tract (OFT) …