Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in
the elimination of damaged mitochondria by autophagy (mitophagy) has provided …

Autophagy is an evolutionarily conserved and tightly regulated process that plays an
important role in maintaining cellular homeostasis. It involves regulation of various genes …

SBI-0206965, originally identified as an inhibitor of the autophagy initiator kinase ULK1, has
recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) …

Autophagy is a cellular process that removes damaged components of cells and recycles
them as biochemical building blocks. Autophagy can also be induced to protect cells in …

Selective autophagy of damaged mitochondria, protein aggregates, and other cargoes is
essential for health. Cargo initiates phagophore biogenesis, which entails the conjugation of …

Reversible protein phosphorylation, catalyzed by protein kinases and phosphatases, is a
fundamental process that controls protein function and intracellular signaling. Failure of …

For many years, it was thought that ATG5 and ATG7 played a pivotal role in autophagy, and
that the knockdown of one of these genes would result in its inhibition. However, cells with …

Bladder cancer (urothelial carcinoma) is one of the most frequently diagnosed neoplasms,
with an estimated half a million new cases and 200,000 deaths per year worldwide. This …

Pancreatic cancer cells with mutant KRAS require strong basal autophagy for viability and
growth. Here, we observed that some processes that allow the maintenance of basal …