Chemogenetic modulation of astrocytes and microglia: State‐of‐the‐art and implications in neuroscience
J Bossuyt, Y Van Den Herrewegen, L Nestor, A Buckinx… - Glia, 2023 - Wiley Online Library
Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …
[HTML][HTML] Blood-spinal cord barrier: its role in spinal disorders and emerging therapeutic strategies
The blood-spinal cord barrier (BSCB) has been long thought of as a functional equivalent to
the blood-brain barrier (BBB), restricting blood flow into the spinal cord. The spinal cord is …
the blood-brain barrier (BBB), restricting blood flow into the spinal cord. The spinal cord is …
[HTML][HTML] Side-by-side comparison of the effects of Gq-and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the …
Y Van Den Herrewegen, TM Sanderson, S Sahu… - Molecular Brain, 2021 - Springer
Astrocytes express a plethora of G protein-coupled receptors (GPCRs) that are crucial for
shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient …
shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient …
[HTML][HTML] Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
A Aly, ZI Laszlo, S Rajkumar, T Demir, N Hindley… - Acta …, 2023 - Springer
Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly
affecting upper and lower motoneurons. Several functionally heterogeneous genes have …
affecting upper and lower motoneurons. Several functionally heterogeneous genes have …
[HTML][HTML] Breached barriers: a scoping review of blood-central nervous system barrier pathology in amyotrophic lateral sclerosis
A Mirian, A Moszczynski, S Soleimani… - Frontiers in Cellular …, 2022 - frontiersin.org
Recent studies have implicated changes in the blood-central nervous system barriers
(BCNSB) in amyotrophic lateral sclerosis (ALS). The objective of this scoping review is to …
(BCNSB) in amyotrophic lateral sclerosis (ALS). The objective of this scoping review is to …
Neurovascular unit pathology is observed very early in disease progression in the mutant SOD1G93A mouse model of amyotrophic lateral sclerosis
M Yoshikawa, S Aizawa, RW Oppenheim… - Experimental …, 2022 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease
characterized by motor neuron degeneration that causes neuromuscular denervation …
characterized by motor neuron degeneration that causes neuromuscular denervation …
[HTML][HTML] Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders
Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity
via the activation of engineered receptors that are pharmacologically selective to …
via the activation of engineered receptors that are pharmacologically selective to …
Patching up the permeability: the role of stem cells in lessening neurovascular damage in amyotrophic lateral sclerosis
M Monsour, S Garbuzova-Davis… - Stem Cells …, 2022 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a debilitating disease with poor prognosis. The
pathophysiology of ALS is commonly debated, with theories involving inflammation …
pathophysiology of ALS is commonly debated, with theories involving inflammation …
[HTML][HTML] Acute TBK1/IKK-ε inhibition enhances the generation of disease-associated microglia-like phenotype upon cortical stab-wound injury
R Rehman, L Tar, AJ Olamide, Z Li… - Frontiers in aging …, 2021 - frontiersin.org
Traumatic brain injury has a poorer prognosis in elderly patients, possibly because of the
enhanced inflammatory response characteristic of advanced age, known as “inflammaging.” …
enhanced inflammatory response characteristic of advanced age, known as “inflammaging.” …
[HTML][HTML] Sarm1 knockout modifies biomarkers of neurodegeneration and spinal cord circuitry but not disease progression in the mSOD1G93A mouse model of ALS
JM Collins, RAK Atkinson, LM Matthews… - Neurobiology of …, 2022 - Elsevier
The mechanisms underlying the loss of motor neuron axon integrity in amyotrophic lateral
sclerosis (ALS) are unclear. SARM1 has been identified as a genetic risk variant in sporadic …
sclerosis (ALS) are unclear. SARM1 has been identified as a genetic risk variant in sporadic …