[PDF][PDF] Cellular pathways influenced by protein arginine methylation: Implications for cancer
Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
[HTML][HTML] DEAD-box RNA helicases and genome stability
M Cargill, R Venkataraman, S Lee - Genes, 2021 - mdpi.com
DEAD-box RNA helicases are important regulators of RNA metabolism and have been
implicated in the development of cancer. Interestingly, these helicases constitute a major …
implicated in the development of cancer. Interestingly, these helicases constitute a major …
[HTML][HTML] APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
JL McCann, A Cristini, EK Law, SY Lee, M Tellier… - Nature Genetics, 2023 - nature.com
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
[HTML][HTML] RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
A Cristini, M Tellier, F Constantinescu, C Accalai… - Nature …, 2022 - nature.com
RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency
of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome …
of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome …
PARP1 associates with R-loops to promote their resolution and genome stability
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
G Sessa, B Gómez‐González, S Silva… - The EMBO …, 2021 - embopress.org
The BRCA2 tumor suppressor is a DNA double‐strand break (DSB) repair factor essential
for maintaining genome integrity. BRCA2‐deficient cells spontaneously accumulate DNA …
for maintaining genome integrity. BRCA2‐deficient cells spontaneously accumulate DNA …
RNA helicase-dependent gene looping impacts messenger RNA processing
S Terrone, J Valat, N Fontrodona, G Giraud… - Nucleic Acids …, 2022 - academic.oup.com
Abstract DDX5 and DDX17 are DEAD-box RNA helicase paralogs which regulate several
aspects of gene expression, especially transcription and splicing, through incompletely …
aspects of gene expression, especially transcription and splicing, through incompletely …
DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions
Z Yu, SY Mersaoui, L Guitton-Sert, Y Coulombe… - NAR …, 2020 - academic.oup.com
R-loops are three-stranded structures consisting of a DNA/RNA hybrid and a displaced DNA
strand. The regulatory factors required to process this fundamental genetic structure near …
strand. The regulatory factors required to process this fundamental genetic structure near …
[HTML][HTML] DDX5 mRNA-targeting antisense oligonucleotide as a new promising therapeutic in combating castration-resistant prostate cancer
The heat shock protein 27 (Hsp27) has emerged as a principal factor of the castration-
resistant prostate cancer (CRPC) progression. Also, an antisense oligonucleotide (ASO) …
resistant prostate cancer (CRPC) progression. Also, an antisense oligonucleotide (ASO) …
Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4
Mutation in the senataxin (SETX) gene causes an autosomal dominant neuromuscular
disorder, amyotrophic lateral sclerosis 4 (ALS4), characterized by degeneration of motor …
disorder, amyotrophic lateral sclerosis 4 (ALS4), characterized by degeneration of motor …