Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia
S Chiappalupi, G Sorci, A Vukasinovic… - Journal of cachexia …, 2020 - Wiley Online Library
Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice
S Scaricamazza, I Salvatori, S Amadio… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease
characterized by the degeneration of upper and lower motor neurons, progressive wasting …
characterized by the degeneration of upper and lower motor neurons, progressive wasting …
[HTML][HTML] NMJ-related diseases beyond the congenital myasthenic syndromes
A Navarro-Martínez, C Vicente-García… - Frontiers in Cell and …, 2023 - ncbi.nlm.nih.gov
Neuromuscular junctions (NMJs) are a special type of chemical synapse that transmits
electrical stimuli from motor neurons (MNs) to their innervating skeletal muscle to induce a …
electrical stimuli from motor neurons (MNs) to their innervating skeletal muscle to induce a …
[HTML][HTML] Functional interaction between the oncogenic kinase NEK2 and Sam68 promotes a splicing program involved in migration and invasion in triple-negative …
C Naro, F Barbagallo, C Caggiano, M De Musso… - Frontiers in …, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer
subtype. Poor prognosis in TNBC is partly due to lack of efficacious targeted therapy and …
subtype. Poor prognosis in TNBC is partly due to lack of efficacious targeted therapy and …
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy
A Renzini, N Marroncelli, G Cavioli… - Journal of Cachexia …, 2022 - Wiley Online Library
Abstract Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that
mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles …
mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles …
Dysregulation of alternative splicing underlies synaptic defects in familial amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease
characterized by the degeneration of upper and lower motor neurons, progressive wasting …
characterized by the degeneration of upper and lower motor neurons, progressive wasting …
[HTML][HTML] pncCCND1_B Engages an Inhibitory Protein Network to Downregulate CCND1 Expression upon DNA Damage
R Palombo, MP Paronetto - Cancers, 2022 - mdpi.com
Simple Summary Ewing sarcoma is a pediatric tumor characterized by chromosomal
translocations, giving rise to the oncogene EWS-FLI1, which triggers the transcription of …
translocations, giving rise to the oncogene EWS-FLI1, which triggers the transcription of …
Structure and function analysis of Sam68 and hnRNP A1 synergy in the exclusion of exon 7 from SMN2 transcripts
M Nadal, R Anton, J Dorca‐Arévalo… - Protein …, 2023 - Wiley Online Library
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the absence of a
functional copy of the Survival of Motor Neuron 1 gene (SMN1). The nearly identical paralog …
functional copy of the Survival of Motor Neuron 1 gene (SMN1). The nearly identical paralog …
[BOOK][B] Women in cancer genetics vol II: 2022
GT Torrezan, P Mehdipour - 2023 - books.google.com
Alternative splicing is the molecular process that generates multiple mRNA variants from
single eukaryotic genes through variable assortment of their exons (1, 2). This process …
single eukaryotic genes through variable assortment of their exons (1, 2). This process …