Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

S Chiappalupi, G Sorci, A Vukasinovic… - Journal of cachexia …, 2020 - Wiley Online Library
Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice

S Scaricamazza, I Salvatori, S Amadio… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease
characterized by the degeneration of upper and lower motor neurons, progressive wasting …

[HTML][HTML] NMJ-related diseases beyond the congenital myasthenic syndromes

A Navarro-Martínez, C Vicente-García… - Frontiers in Cell and …, 2023 - ncbi.nlm.nih.gov
Neuromuscular junctions (NMJs) are a special type of chemical synapse that transmits
electrical stimuli from motor neurons (MNs) to their innervating skeletal muscle to induce a …

[HTML][HTML] Functional interaction between the oncogenic kinase NEK2 and Sam68 promotes a splicing program involved in migration and invasion in triple-negative …

C Naro, F Barbagallo, C Caggiano, M De Musso… - Frontiers in …, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer
subtype. Poor prognosis in TNBC is partly due to lack of efficacious targeted therapy and …

Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy

A Renzini, N Marroncelli, G Cavioli… - Journal of Cachexia …, 2022 - Wiley Online Library
Abstract Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that
mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles …

Dysregulation of alternative splicing underlies synaptic defects in familial amyotrophic lateral sclerosis

V Verdile, R Palombo, G Ferrante, A Ferri… - Progress in …, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease
characterized by the degeneration of upper and lower motor neurons, progressive wasting …

[HTML][HTML] pncCCND1_B Engages an Inhibitory Protein Network to Downregulate CCND1 Expression upon DNA Damage

R Palombo, MP Paronetto - Cancers, 2022 - mdpi.com
Simple Summary Ewing sarcoma is a pediatric tumor characterized by chromosomal
translocations, giving rise to the oncogene EWS-FLI1, which triggers the transcription of …

Structure and function analysis of Sam68 and hnRNP A1 synergy in the exclusion of exon 7 from SMN2 transcripts

M Nadal, R Anton, J Dorca‐Arévalo… - Protein …, 2023 - Wiley Online Library
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the absence of a
functional copy of the Survival of Motor Neuron 1 gene (SMN1). The nearly identical paralog …

[BOOK][B] Women in cancer genetics vol II: 2022

GT Torrezan, P Mehdipour - 2023 - books.google.com
Alternative splicing is the molecular process that generates multiple mRNA variants from
single eukaryotic genes through variable assortment of their exons (1, 2). This process …