Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by lipid
accumulation in hepatocytes in the absence of excessive alcohol consumption. The global …

Defective degradation of intracellular lipids induced by autophagy is causally linked to the
development of non‐alcoholic fatty liver disease (NAFLD). Natural agents that can restore …

Sequestosome 1 (SQSTM1/p62; hereafter p62) is an autophagy receptor protein for
selective autophagy primarily due to its direct interaction with the microtubule light chain 3 …

Steatosis is the accumulation of neutral lipids in the cytoplasm. In the liver, it is associated
with overeating and a sedentary lifestyle, but may also be a result of xenobiotic toxicity and …

Lipid droplets (LDs) are not an inert storage of excessive lipids, but play various roles in
cellular lipid metabolism. Autophagy involves several mechanisms for the degradation of …

Lipotoxicity is a phenomenon of lipid-induced cellular injury in nonadipose tissue. Excess of
free saturated fatty acids (SFAs) contributes to hepatic injury in nonalcoholic fatty liver …

As a promising group of natural bioactive lipids, ether-phospholipids (ether-PLs), exhibit the
ability to attenuate high-fat diet (HFD)-induced lipid accumulation and atherosclerosis …