[HTML][HTML] Mitochondrial fusion: the machineries in and out
S Gao, J Hu - Trends in cell biology, 2021 - cell.com
Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …
Disruption of mitochondrial dynamics undermines their function and causes several human …
[HTML][HTML] Dietary supplements and natural products: an update on their clinical effectiveness and molecular mechanisms of action during accelerated biological aging
Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …
and the distortion of physiological processes, underlies several human diseases. Away from …
[HTML][HTML] Mitochondrial quality control governed by ubiquitin
Mitochondria are essential organelles important for energy production, proliferation, and cell
death. Biogenesis, homeostasis, and degradation of this organelle are tightly controlled to …
death. Biogenesis, homeostasis, and degradation of this organelle are tightly controlled to …
[HTML][HTML] Protein quality control at the mitochondrial surface
F den Brave, A Gupta, T Becker - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Mitochondria contain two membranes, the outer and inner membrane. The outer membrane
fulfills crucial functions for the communication of mitochondria with the cellular environment …
fulfills crucial functions for the communication of mitochondria with the cellular environment …
[HTML][HTML] Mitochondrial surveillance by Cdc48/p97: MAD vs. membrane fusion
M Escobar-Henriques, V Anton - International Journal of Molecular …, 2020 - mdpi.com
Cdc48/p97 is a ring-shaped, ATP-driven hexameric motor, essential for cellular viability. It
specifically unfolds and extracts ubiquitylated proteins from membranes or protein …
specifically unfolds and extracts ubiquitylated proteins from membranes or protein …
[PDF][PDF] E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
V Anton, I Buntenbroich, T Simões, M Joaquim… - Molecular Cell, 2023 - cell.com
Ubiquitin-dependent control of mitochondrial dynamics is important for protein quality and
neuronal integrity. Mitofusins, mitochondrial fusion factors, can integrate cellular stress …
neuronal integrity. Mitofusins, mitochondrial fusion factors, can integrate cellular stress …
[PDF][PDF] Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target
I Buntenbroich, V Anton, D Perez-Hernandez, T Simões… - Iscience, 2023 - cell.com
Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power
membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly …
membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly …
Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
R Schuster, V Anton, T Simões, S Altin… - Life science …, 2020 - life-science-alliance.org
Mitochondria are essential organelles whose function is upheld by their dynamic nature.
This plasticity is mediated by large dynamin-related GTPases, called mitofusins in the case …
This plasticity is mediated by large dynamin-related GTPases, called mitofusins in the case …
A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering
SR Sloat, S Hoppins - Life Science Alliance, 2023 - life-science-alliance.org
In vertebrates, mitochondrial outer membrane fusion is mediated by two mitofusin paralogs,
Mfn1 and Mfn2, conserved dynamin superfamily proteins. Here, we characterize a variant of …
Mfn1 and Mfn2, conserved dynamin superfamily proteins. Here, we characterize a variant of …
Analysis of protein stability by synthesis shutoff
I Buntenbroich, T Simões, M Escobar-Henriques - Bio-protocol, 2021 - bio-protocol.org
In this protocol, we describe the analysis of protein stability over time, using synthesis
shutoff. As an example, we express HA-tagged yeast mitofusin Fzo1 in Saccharomyces …
shutoff. As an example, we express HA-tagged yeast mitofusin Fzo1 in Saccharomyces …