[HTML][HTML] Mitochondrial fusion: the machineries in and out

S Gao, J Hu - Trends in cell biology, 2021 - cell.com
Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …

[HTML][HTML] Dietary supplements and natural products: an update on their clinical effectiveness and molecular mechanisms of action during accelerated biological aging

Y Chen, S Hamidu, X Yang, Y Yan, Q Wang, L Li… - Frontiers in …, 2022 - frontiersin.org
Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …

[HTML][HTML] Mitochondrial quality control governed by ubiquitin

S Ravanelli, F Den Brave, T Hoppe - Frontiers in Cell and …, 2020 - frontiersin.org
Mitochondria are essential organelles important for energy production, proliferation, and cell
death. Biogenesis, homeostasis, and degradation of this organelle are tightly controlled to …

[HTML][HTML] Protein quality control at the mitochondrial surface

F den Brave, A Gupta, T Becker - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Mitochondria contain two membranes, the outer and inner membrane. The outer membrane
fulfills crucial functions for the communication of mitochondria with the cellular environment …

[HTML][HTML] Mitochondrial surveillance by Cdc48/p97: MAD vs. membrane fusion

M Escobar-Henriques, V Anton - International Journal of Molecular …, 2020 - mdpi.com
Cdc48/p97 is a ring-shaped, ATP-driven hexameric motor, essential for cellular viability. It
specifically unfolds and extracts ubiquitylated proteins from membranes or protein …

[PDF][PDF] E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response

V Anton, I Buntenbroich, T Simões, M Joaquim… - Molecular Cell, 2023 - cell.com
Ubiquitin-dependent control of mitochondrial dynamics is important for protein quality and
neuronal integrity. Mitofusins, mitochondrial fusion factors, can integrate cellular stress …

[PDF][PDF] Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target

I Buntenbroich, V Anton, D Perez-Hernandez, T Simões… - Iscience, 2023 - cell.com
Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power
membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly …

Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation

R Schuster, V Anton, T Simões, S Altin… - Life science …, 2020 - life-science-alliance.org
Mitochondria are essential organelles whose function is upheld by their dynamic nature.
This plasticity is mediated by large dynamin-related GTPases, called mitofusins in the case …

A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering

SR Sloat, S Hoppins - Life Science Alliance, 2023 - life-science-alliance.org
In vertebrates, mitochondrial outer membrane fusion is mediated by two mitofusin paralogs,
Mfn1 and Mfn2, conserved dynamin superfamily proteins. Here, we characterize a variant of …

Analysis of protein stability by synthesis shutoff

I Buntenbroich, T Simões, M Escobar-Henriques - Bio-protocol, 2021 - bio-protocol.org
In this protocol, we describe the analysis of protein stability over time, using synthesis
shutoff. As an example, we express HA-tagged yeast mitofusin Fzo1 in Saccharomyces …