Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver

A Shin, DJ Waxman - Toxicological Sciences, 2022 - academic.oup.com
Perinatal exposure to environmental chemicals is proposed to reprogram development and
alter disease susceptibility later in life. Supporting this, neonatal activation of the nuclear …

Widespread dysregulation of long noncoding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed …

K Karri, DJ Waxman - Toxicological Sciences, 2020 - academic.oup.com
Xenobiotic exposure dysregulates hundreds of protein-coding genes in mammalian liver,
impacting many physiological processes and inducing diverse toxicological responses. Little …

Fluorescence approaches for biochemical analysis of ATP-dependent chromatin remodeling enzymes

AS Baier, CL Peterson - Methods in enzymology, 2022 - Elsevier
The dynamic nature of chromatin is an essential mechanism by which gene expression is
regulated. Chromatin is comprised of nucleosomes, an octamer of histone proteins wrapped …

Biochemical Investigations into the S. cerevisiae Chromatin Remodeling Enzyme SWR1C

AS Baier - 2023 - repository.escholarship.umassmed …
Chromatin refers to the higher-order organization of DNA in the nucleus of the cell, and this
architecture fundamentally underpins essential cellular processes such as response to …

[HTML][HTML] Nuclear morphometry and chromatin texture changes in hepatocellular carcinoma samples may predict outcomes of liver transplanted patients

JB Dos Santos, RT Starosta, EFS Pilar, JD Kunz… - BMC …, 2022 - Springer
Background Nuclear changes are typical in the carcinogenesis of hepatocellular carcinoma
(HCC). Morphometry and chromatin texture analysis are quantitative methods for their …

Nuclear Morphometry and Chromatin Texture Changes in Hepatocellular Carcinoma Samples May Predict Liver Transplant Patients' Outcomes

JB dos Santos, RT Starosta, EFS Pilar, JD Kunz… - 2022 - researchsquare.com
Background: Nuclear changes are typical in the carcinogenesis of hepatocellular carcinoma
(HCC). Morphometry and chromatin texture analysis are quantitative methods for their …

Bioinformatics/Impact of Computational Biology for Molecular Safety Assessment during Drug Development

J Perner, M Onishi-Seebacher… - Current Topics in …, 2020 - taylorfrancis.com
The rapid evolution of bioinformatics applications in toxicology, together with game-
changing advances in molecular profiling technologies, such as deep sequencing, has led …

Juliane Perner, Megumi Onishi-Seebacher, Alberto Del Rio Espinola, Elaine Tritto, Philippe

RT Couttet, J Moggs - Current Topics in Nonclinical Drug …, 2020 - books.google.com
Established toxicology disciplines, such as the in silico prediction of adverse events
associated with chemical structures, in vitro secondary pharmacology screening for off …