[HTML][HTML] Strategies to target ADAM17 in disease: from its discovery to the iRhom revolution

M Calligaris, D Cuffaro, S Bonelli, DP Spanò… - Molecules, 2021 - mdpi.com
For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

[HTML][HTML] Thiol switches in membrane proteins-Extracellular redox regulation in cell biology

I Lorenzen, JA Eble, EM Hanschmann - Biological Chemistry, 2021 - degruyter.com
Redox-mediated signal transduction depends on the enzymatic production of second
messengers such as hydrogen peroxide, nitric oxide and hydrogen sulfite, as well as …

[HTML][HTML] Role of ADAM10 and ADAM17 in Regulating CD137 Function

J Seidel, S Leitzke, B Ahrens, M Sperrhacke… - International Journal of …, 2021 - mdpi.com
Human CD137 (4-1BB), a member of the TNF receptor family, and its ligand CD137L (4-
1BBL), are expressed on immune cells and tumor cells. CD137/CD137L interaction …

[HTML][HTML] Scramblases as Regulators of Proteolytic ADAM Function

K Reiss, S Leitzke, J Seidel, M Sperrhacke, S Bhakdi - Membranes, 2022 - mdpi.com
Proteolytic ectodomain release is a key mechanism for regulating the function of many cell
surface proteins. The sheddases ADAM10 and ADAM17 are the best-characterized …

[HTML][HTML] Inactive Rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): A decade of research in murine models

LM Burzenski, BE Low, V Kohar, LD Shultz… - Mammalian …, 2021 - Springer
Rhomboid proteases, first discovered in Drosophila, are intramembrane serine proteases.
Members of the rhomboid protein family that are catalytically deficient are known as inactive …

Distance dependent shedding of IL-6R

S Düsterhöft, AK Bartels, T Koudelka… - Biochemical and …, 2020 - Elsevier
Proteolytic processing of membrane proteins by A disintegrin and metalloprotease-17
(ADAM17) is a key regulatory step in many physiological and pathophysiological processes …

Roles of ADAM10 and 17 in the shedding of LRP1 in human macrophages

MB Markham - 2024 - ueaeprints.uea.ac.uk
The inflammatory cytokine TNF has a central role in regulating the inflammatory response,
and prolonged TNF release is observed in many chronic inflammatory diseases. The …

Understanding Proteolytic Processing of Melanoma Cell Adhesion Molecule (MCAM) in Cutaneous Melanoma

T George - 2023 - espace.curtin.edu.au
Melanoma is a type of skin cancer and is one of the most common cancers in Australia. Due
to the aggressive nature of melanoma, an improved understanding of its progression is …

[PDF][PDF] ADAM10 und-17 als Regulatoren der CD137-Funktion

J Seidel - 2021 - macau.uni-kiel.de
Die Proteolyse ist eine der wichtigsten posttranslationalen Modifikationen und ein
entscheidender Regulationsmechanismus für Zellen. Durch hydrolytische Spaltung, die …