Division and transmission: malaria parasite development in the mosquito

DS Guttery, M Zeeshan, DJP Ferguson… - Annual Review of …, 2022 - annualreviews.org
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

[HTML][HTML] Expansion microscopy of Plasmodium gametocytes reveals the molecular architecture of a bipartite microtubule organisation centre coordinating mitosis with …

R Rashpa, M Brochet - PLoS Pathogens, 2022 - journals.plos.org
Transmission of malaria-causing parasites to mosquitoes relies on the production of
gametocyte stages and their development into gametes. These stages display various …

[HTML][HTML] Expansion microscopy provides new insights into the cytoskeleton of malaria parasites including the conservation of a conoid

E Bertiaux, AC Balestra, L Bournonville, V Louvel… - PLoS …, 2021 - journals.plos.org
Malaria is caused by unicellular Plasmodium parasites. Plasmodium relies on diverse
microtubule cytoskeletal structures for its reproduction, multiplication, and dissemination …

[HTML][HTML] Sexual development in non-human parasitic apicomplexa: just biology or targets for control?

T Cruz-Bustos, AS Feix, B Ruttkowski, A Joachim - Animals, 2021 - mdpi.com
Simple Summary Cellular reproduction is a key part of the apicomplexan life cycle, and both
mitotic (asexual) and meiotic (sexual) cell divisions produce new individual cells. Sexual …

Plasmodium falciparum calcium-dependent protein kinase 4 is critical for male gametogenesis and transmission to the mosquito vector

S Kumar, MT Haile, MR Hoopmann, LT Tran… - MBio, 2021 - Am Soc Microbiol
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with
an infectious blood meal, representing a critical stage for parasite transmission. Calcium …

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

AC Balestra, M Zeeshan, E Rea, C Pasquarello… - Elife, 2020 - elifesciences.org
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent
kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique …

[HTML][HTML] Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages

M Zeeshan, E Rea, S Abel, K Vukušić, R Markus… - Nature …, 2023 - nature.com
The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …

Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation

M Zeeshan, R Pandey, DJP Ferguson… - Journal of cell …, 2021 - journals.biologists.com
Eukaryotic cell proliferation requires chromosome replication and precise segregation to
ensure daughter cells have identical genomic copies. Species of the genus Plasmodium, the …

[HTML][HTML] Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

M Zeeshan, F Shilliday, T Liu, S Abel, T Mourier… - PLoS …, 2019 - journals.plos.org
Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic
spindle length and chromosome alignment. They move towards the plus ends of spindle …

Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission

M Zeeshan, D Brady, R Markus… - Life science …, 2022 - life-science-alliance.org
The centriole/basal body (CBB) is an evolutionarily conserved organelle acting as a
microtubule organising centre (MTOC) to nucleate cilia, flagella, and the centrosome …