Division and transmission: malaria parasite development in the mosquito
DS Guttery, M Zeeshan, DJP Ferguson… - Annual Review of …, 2022 - annualreviews.org
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …
[HTML][HTML] Expansion microscopy of Plasmodium gametocytes reveals the molecular architecture of a bipartite microtubule organisation centre coordinating mitosis with …
R Rashpa, M Brochet - PLoS Pathogens, 2022 - journals.plos.org
Transmission of malaria-causing parasites to mosquitoes relies on the production of
gametocyte stages and their development into gametes. These stages display various …
gametocyte stages and their development into gametes. These stages display various …
[HTML][HTML] Expansion microscopy provides new insights into the cytoskeleton of malaria parasites including the conservation of a conoid
Malaria is caused by unicellular Plasmodium parasites. Plasmodium relies on diverse
microtubule cytoskeletal structures for its reproduction, multiplication, and dissemination …
microtubule cytoskeletal structures for its reproduction, multiplication, and dissemination …
[HTML][HTML] Sexual development in non-human parasitic apicomplexa: just biology or targets for control?
T Cruz-Bustos, AS Feix, B Ruttkowski, A Joachim - Animals, 2021 - mdpi.com
Simple Summary Cellular reproduction is a key part of the apicomplexan life cycle, and both
mitotic (asexual) and meiotic (sexual) cell divisions produce new individual cells. Sexual …
mitotic (asexual) and meiotic (sexual) cell divisions produce new individual cells. Sexual …
Plasmodium falciparum calcium-dependent protein kinase 4 is critical for male gametogenesis and transmission to the mosquito vector
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with
an infectious blood meal, representing a critical stage for parasite transmission. Calcium …
an infectious blood meal, representing a critical stage for parasite transmission. Calcium …
A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent
kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique …
kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique …
[HTML][HTML] Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages
The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …
Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation
Eukaryotic cell proliferation requires chromosome replication and precise segregation to
ensure daughter cells have identical genomic copies. Species of the genus Plasmodium, the …
ensure daughter cells have identical genomic copies. Species of the genus Plasmodium, the …
[HTML][HTML] Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission
Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic
spindle length and chromosome alignment. They move towards the plus ends of spindle …
spindle length and chromosome alignment. They move towards the plus ends of spindle …
Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission
M Zeeshan, D Brady, R Markus… - Life science …, 2022 - life-science-alliance.org
The centriole/basal body (CBB) is an evolutionarily conserved organelle acting as a
microtubule organising centre (MTOC) to nucleate cilia, flagella, and the centrosome …
microtubule organising centre (MTOC) to nucleate cilia, flagella, and the centrosome …