[HTML][HTML] Better together: circulating tumor cell clustering in metastatic cancer
E Schuster, R Taftaf, C Reduzzi, MK Albert… - Trends in cancer, 2021 - cell.com
Circulating tumor cells (CTCs) are vital components of liquid biopsies for diagnosis of
residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific …
residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific …
[HTML][HTML] Dynamics of phenotypic heterogeneity associated with EMT and stemness during cancer progression
MK Jolly, T Celià-Terrassa - Journal of clinical medicine, 2019 - mdpi.com
Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell
populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to …
populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to …
Cancer extracellular vesicles, tumoroid models, and tumor microenvironment
Cancer extracellular vesicles (EVs), or exosomes, promote tumor progression through
enhancing tumor growth, initiating epithelial-to-mesenchymal transition, remodeling the …
enhancing tumor growth, initiating epithelial-to-mesenchymal transition, remodeling the …
[HTML][HTML] Fibroblasts as turned agents in cancer progression
R Wieder - Cancers, 2023 - mdpi.com
Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …
an ecosystem made up of a variety of cells and proteins that support their intended functions …
[HTML][HTML] Dangerous liaisons: circulating tumor cells (CTCs) and cancer-associated fibroblasts (CAFs)
P Hurtado, I Martínez-Pena, R Piñeiro - Cancers, 2020 - mdpi.com
Simple Summary Circulating tumor cell clusters (CTC clusters) seem to play a primary role in
the metastatic spread of cancer, the main cause of death associated with this disease. The …
the metastatic spread of cancer, the main cause of death associated with this disease. The …
Collective metastasis: coordinating the multicellular voyage
E Wrenn, Y Huang, K Cheung - Clinical & experimental metastasis, 2021 - Springer
The metastatic process is arduous. Cancer cells must escape the confines of the primary
tumor, make their way into and travel through the circulation, then survive and proliferate in …
tumor, make their way into and travel through the circulation, then survive and proliferate in …
[HTML][HTML] Transforming growth factor-β: an agent of change in the tumor microenvironment
CH Stuelten, YE Zhang - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult
tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early stage …
tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early stage …
[PDF][PDF] Interplay between tumor microenvironment and partial EMT as the driver of tumor progression
Epithelial-to-mesenchymal transition (EMT), an evolutionary conserved phenomenon, has
been extensively studied to address the unresolved variable treatment response across …
been extensively studied to address the unresolved variable treatment response across …
[HTML][HTML] Dual role of fibroblasts educated by tumour in cancer behavior and therapeutic perspectives
Tumours are complex systems with dynamic interactions between tumour cells, non-tumour
cells, and extracellular components that comprise the tumour microenvironment (TME). The …
cells, and extracellular components that comprise the tumour microenvironment (TME). The …
[HTML][HTML] Chemotherapy-induced release of circulating-tumor cells into the bloodstream in collective migration units with cancer-associated fibroblasts in metastatic …
N Ortiz-Otero, JR Marshall, B Lash, MR King - BMC cancer, 2020 - Springer
Background Recent studies have shown that chemotherapy destabilizes the blood
vasculature and increases circulating tumor cell (CTC) influx into the circulation of metastatic …
vasculature and increases circulating tumor cell (CTC) influx into the circulation of metastatic …