[HTML][HTML] Functional mammalian amyloids and amyloid-like proteins

MS Rubel, SA Fedotov, AV Grizel, JV Sopova… - Life, 2020 - mdpi.com
Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily
because of association with a variety of incurable human and animal diseases (termed …

RNA-binding and prion domains: the Yin and Yang of phase separation

NL Gotor, A Armaos, G Calloni… - Nucleic acids …, 2020 - academic.oup.com
Proteins and RNAs assemble in membrane-less organelles that organize intracellular
spaces and regulate biochemical reactions. The ability of proteins and RNAs to form …

Response to stress in biological disorders: Implications of stress granule assembly and function

L Wang, W Yang, B Li, S Yuan, F Wang - Cell Proliferation, 2021 - Wiley Online Library
It is indispensable for cells to adapt and respond to environmental stresses, in order for
organisms to survive. Stress granules (SGs) are condensed membrane‐less organelles …

Intercellular transmission of a synthetic bacterial cytotoxic prion-like protein in mammalian cells

A Revilla-García, C Fernández, M Moreno-del Álamo… - MBio, 2020 - Am Soc Microbiol
RepA is a bacterial protein that builds intracellular amyloid oligomers acting as inhibitory
complexes of plasmid DNA replication. When carrying a mutation enhancing its …

Proteins in assemblages formed by phase separation possess properties that promote their transformation to autoantigens: Implications for autoimmunity

PL Carl, HM Fried, PL Cohen - Journal of Autoimmunity, 2020 - Elsevier
Autoantibodies in systemic autoimmunity are directed against only~ 5% of the proteome.
The purpose of this study was to assess whether the properties of assemblages (also known …

Intercellular transmission of a bacterial cytotoxic prion-like protein in mammalian cells

A Revilla-García, C Fernández, MM Álamo… - bioRxiv, 2019 - biorxiv.org
RepA is a bacterial protein that builds intracellular amyloid oligomers acting as inhibitory
complexes of plasmid DNA replication. When carrying a mutation enhancing its …