[HTML][HTML] An integrated transport mechanism of the maltose ABC importer

R Mächtel, A Narducci, DA Griffith, T Cordes… - Research in …, 2019 - Elsevier
ATP-binding cassette (ABC) transporters use the energy of ATP hydrolysis to transport a
large diversity of molecules actively across biological membranes. A combination of …

The Gram-negative permeability barrier: tipping the balance of the in and the out

C Maher, KA Hassan - Mbio, 2023 - Am Soc Microbiol
Gram-negative bacteria are intrinsically resistant to many antibiotics, due in large part to the
permeability barrier formed by their cell envelope. The complex and synergistic interplay of …

[HTML][HTML] Maltotriose-based probes for fluorescence and photoacoustic imaging of bacterial infections

A Zlitni, G Gowrishankar, I Steinberg… - Nature …, 2020 - nature.com
Currently, there are no non-invasive tools to accurately diagnose wound and surgical site
infections before they become systemic or cause significant anatomical damage …

[HTML][HTML] Novel gold (III)-dithiocarbamate complex targeting bacterial thioredoxin reductase: Antimicrobial activity, synergy, toxicity, and mechanistic insights

C Ratia, V Ballén, Y Gabasa, RG Soengas… - Frontiers in …, 2023 - frontiersin.org
Introduction Antimicrobial resistance is a pressing global concern that has led to the search
for new antibacterial agents with novel targets or non-traditional approaches. Recently …

Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development

A Bali, MAM Kamal, G Mulla, B Loretz… - Advanced Functional …, 2023 - Wiley Online Library
With the emerging problem of antimicrobial resistance, the world is facing a slow but
dangerous pandemic. While the discovery of novel antibiotics is reaching a nearly …

Atomistic simulation of molecules interacting with biological nanopores: from current understanding to future directions

A Acharya, JD Prajapati… - The Journal of Physical …, 2022 - ACS Publications
Biological nanopores have been at the focus of numerous studies due to their role in many
biological processes as well as their (prospective) technological applications. Among many …

[HTML][HTML] Mechanism of Resistance Development in E. coli against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic

AI Lauxen, P Kobauri, M Wegener, MJ Hansen… - Pharmaceuticals, 2021 - mdpi.com
During the last decades, a continuous rise of multi-drug resistant pathogens has threatened
antibiotic efficacy. To tackle this key challenge, novel antimicrobial therapies are needed …

[HTML][HTML] From differential stains to next generation physiology: chemical probes to visualize bacterial cell structure and physiology

J Hira, MJ Uddin, MM Haugland, CS Lentz - Molecules, 2020 - mdpi.com
Chemical probes have been instrumental in microbiology since its birth as a discipline in the
19th century when chemical dyes were used to visualize structural features of bacterial cells …

[HTML][HTML] Biotinylation as a tool to enhance the uptake of small molecules in Gram-negative bacteria

A Pandeya, L Yang, O Alegun, C Karunasena, C Risko… - Plos one, 2021 - journals.plos.org
Antibiotic resistance is a major public health concern. The shrinking selection of effective
antibiotics and lack of new development is making the situation worse. Gram-negative …

Pharma‐molecule Transport across Bacterial Membranes: Detection and Quantification Approaches by Electrochemistry and Bioanalytical Methods

A Golubchik, LC Lopes, V Singh… - Angewandte Chemie, 2021 - Wiley Online Library
Antibiotic resistance is a significant challenge encountered by healthcare systems on a
global scale. Knowledge about membrane transport of antibiotics and other …