Cancer genomic, transcriptomic, and proteomic profiling has generated extensive data that
necessitate the development of tools for its analysis and dissemination. We developed …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the
dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …

The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is
controversial, constraining implementation of AR-directed therapies. Using a diverse …

The limited efficacy of immune checkpoint inhibitor treatment in triple-negative breast cancer
(TNBC) patients is attributed to sparse or unresponsive tumor-infiltrating lymphocytes, but …

Despite remarkable clinical efficacy of immune checkpoint blockade (ICB) in cancer
treatment, ICB benefits for triple-negative breast cancer (TNBC) remain limited. Through …

Higher-order chromatin structure is important for the regulation of genes by distal regulatory
sequences,. Structural variants (SVs) that alter three-dimensional (3D) genome organization …

Metastatic castration-resistant prostate cancer (mCRPC) has a highly complex genomic
landscape. With the recent development of novel treatments, accurate stratification …

The first lineage specification of pluripotent mouse epiblast segregates neuroectoderm (NE)
from mesoderm and definitive endoderm (ME) by mechanisms that are not well understood …

The ubiquitin-proteasome system (UPS) is the primary route for selective protein
degradation in human cells. The UPS is an attractive target for novel cancer therapies, but …