[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly

S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …

Molecular mechanisms of environmental exposures and human disease

H Wu, CM Eckhardt, AA Baccarelli - Nature Reviews Genetics, 2023 - nature.com
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

[HTML][HTML] A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA

S Zaccara, SR Jaffrey - Cell, 2020 - cell.com
Summary N 6-methyladenosine (m 6 A) is the most abundant mRNA nucleotide modification
and regulates critical aspects of cellular physiology and differentiation. m 6 A is thought to …

m6A enhances the phase separation potential of mRNA

RJ Ries, S Zaccara, P Klein, A Olarerin-George… - Nature, 2019 - nature.com
Abstract N 6-methyladenosine (m6A) is the most prevalent modified nucleotide in mRNA,,
with around 25% of mRNAs containing at least one m6A. Methylation of mRNA to form m6A …

[PDF][PDF] Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

L Jiang, W Lin, C Zhang, PEA Ash, M Verma, J Kwan… - Molecular cell, 2021 - cell.com
The microtubule-associated protein tau oligomerizes, but the actions of oligomeric tau
(oTau) are unknown. We have used Cry2-based optogenetics to induce tau oligomers (oTau …

Alternative ORFs and small ORFs: shedding light on the dark proteome

MW Orr, Y Mao, G Storz, SB Qian - Nucleic Acids Research, 2020 - academic.oup.com
Traditional annotation of protein-encoding genes relied on assumptions, such as one open
reading frame (ORF) encodes one protein and minimal lengths for translated proteins. With …

RNA modifications in physiology and disease: towards clinical applications

S Delaunay, M Helm, M Frye - Nature Reviews Genetics, 2024 - nature.com
The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

[HTML][HTML] The integral role of RNA in stress granule formation and function

D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

m6A-binding YTHDF proteins promote stress granule formation

Y Fu, X Zhuang - Nature chemical biology, 2020 - nature.com
Diverse RNAs and RNA-binding proteins form phase-separated, membraneless granules in
cells under stress conditions. However, the role of the prevalent mRNA methylation, m6A …

[PDF][PDF] Spatiotemporal proteomic analysis of stress granule disassembly using APEX reveals regulation by SUMOylation and links to ALS pathogenesis

H Marmor-Kollet, A Siany, N Kedersha, N Knafo… - Molecular cell, 2020 - cell.com
Stress granules (SGs) are cytoplasmic assemblies of proteins and non-translating mRNAs.
Whereas much has been learned about SG formation, a major gap remains in …