Chromatin functions are influenced by the addition, removal, and recognition of histone post-
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …

The disproportionately high prevalence of male cancer is poorly understood. We tested for
sex-disparity in the functional integrity of the major tumor suppressor p53 in sporadic …

The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved
in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have …

Eukaryotic genomes are duplicated from thousands of replication origins that fire
sequentially forming a defined spatiotemporal pattern of replication clusters. The temporal …

Pharmacologic inhibitors of cellular hydroxylase oxygen sensors are protective in multiple
preclinical in vivo models of inflammation. However, the molecular mechanisms underlying …

Imbalance in the level of the pyrimidine degradation products dihydrouracil and
dihydrothymine is associated with cellular transformation and cancer progression …

Despite the effectiveness of hepatitis B virus (HBV) vaccination in reducing the prevalence of
chronic HBV infection as well as the incidence of acute hepatitis B, fulminant hepatitis, liver …

Faithful DNA replication requires specific proteins that protect replication forks and so
prevent the formation of DNA lesions that may damage the genome. Identification of new …

Ubiquitination is involved in the regulation of numerous cellular functions. Research works
in the ubiquitin realm rely heavily on ubiquitination assays in vitro and require large amounts …

Glioblastoma multiforme (GBM) is a brain tumor with high mortality and recurrence rate.
Radiotherapy and chemotherapy after surgery are the main treatment options available for …