Most humans become infected with Epstein–Barr virus (EBV), which then persists for life.
Infrequently, EBV infection causes infectious mononucleosis (IM) or Burkitt lymphoma (BL). …

Natural killer (NK) cells are lymphocytes that have vital functions in innate and adaptive
immunity, as well as placental reproduction. Polymorphic human leukocyte antigen (HLA) class I …

In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a
peptide and take it to the cell surface for surveillance by lymphocytes. These include natural …

The interactions of killer Ig–like receptor 2D (KIR2D) with HLA-C ligands contribute to
functional NK cell education and regulate NK cell functions. Although simple alloreactive rules …

Human NK cells are usually defined as CD3 - CD56 + lymphocytes. However, a CD56 - CD16
+ (CD56neg) lymphocyte population that displays NK-associated markers expands during …

Humans form 2 groups based on their innate immunity to Epstein-Barr virus (EBV). Group 1
makes a strong natural killer (NK)–cell and γδ T-cell response, whereas group 2 makes a …

HLA-B ∗ 46:01 was formed by an intergenic mini-conversion, between HLA-B ∗ 15:01 and
HLA-C ∗ 01:02, in Southeast Asia during the last 50,000 years, and it has since become the …

NK‐cell functions are regulated by many activating and inhibitory receptors including
KIR3DL1. Extensive allelic polymorphism and variability in expression can directly alter NK‐cell …

Among innate cells, natural killer (NK) cells play a crucial role in the defense against
cytomegalovirus (CMV). In some individuals, CMV infection induces the expansion of NKG2C+ NK …

Leukocyte immunoglobulin-like receptor B1 (LILRB1) is widely expressed on various immune
cells and the engagement of LILRB1 to HLA class I and pathogen-derived proteins can …