Nicotinic acetylcholine receptors are pentameric ion channels that mediate fast chemical
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between the …

Most general anaesthetics and classical benzodiazepine drugs act through positive modulation
of γ-aminobutyric acid type A (GABA A ) receptors to dampen neuronal activity in the …

The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that modulates
neuronal excitability, largely by allowing Ca 2+ permeation. Agonist binding promotes …

Oxford, Oxford, United Kingdom, 3School of Chemistry, University of Bristol, Bristol, United
Kingdom, 4Biological Science, University of Calgary, Calgary, AB, Canada, 5Department of …

This paper presents a planning and real-time pricing approach for EV charging stations (CSs).
The approach takes the form of a bi-level model to fully consider the interest of both the …

γ-Aminobutyric acid type A (GABA A ) receptors mediate fast inhibitory signaling in the brain
and are targets of numerous drugs and endogenous neurosteroids. A subset of …

The neurotransmitter γ-aminobutyric acid (GABA) drives critical inhibitory processes in and
beyond the nervous system, partly via ionotropic type-A receptors (GABA A Rs). …

Diverse and controllable pathways induced by palladium-catalyzed intramolecular Heck
reaction of N-vinylacetamides for the synthesis of nitrogen-containing products in reasonable to …

SARS-CoV-2 contains four structural proteins in its genome. These proteins aid in the assembly
and budding of new virions at the ER-Golgi intermediate compartment (ERGIC). Current …

Ligand-gated ion channels are critical mediators of electrochemical signal transduction
across evolution. Biophysical and pharmacological characterization of these receptor proteins …