Portal vein tumor thrombus (PVTT) is strongly correlated to a poor prognosis for patients
with hepatocellular carcinoma (HCC). In this study, we uncovered a causative link between …

More than 40% of patients with late-stage colorectal cancer (CRC) develop liver metastasis (LM).
Which immune cells play important roles in CRC-LM and contribute to the difference …

Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug
resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive …

Obesity is associated with both endoplasmic reticulum (ER) stress and chronic metabolic
inflammation. ER stress activates the unfolded protein response (UPR) and has been …

Epithelial-to-mesenchymal transition (EMT) promotes both tumor progression and drug
resistance, yet few vulnerabilities of this state have been identified. Using selective small …

Burst-forming unit erythroid progenitors (BFU-Es) are so named based on their ability to
generate in methylcellulose culture large colonies of erythroid cells that consist of “bursts” of …

PERK signaling is required for cancer invasion and there is interest in targeting this pathway
for therapy. Unfortunately, chemical inhibitors of PERK’s kinase activity cause on-target side …

Surgical resection is the first‐line treatment for hepatocellular carcinoma (HCC) patients with
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years …

Eph receptors are implicated in regulating the malignant progression of cancer. Here we
find that despite overexpression of EphB3 in human non-small-cell lung cancer, as reported …

Eph receptors, the largest subfamily of transmembrane tyrosine kinase receptors, have been
increasingly implicated in various physiologic and pathologic processes, and the roles of …