Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification, assortative …

Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …

Objectives To analyze whether frailty and comorbidities are associated with in-hospital
mortality and discharge to home in older adults hospitalized for coronavirus disease 2019 (COVID…

Biological age measurements (BAs) assess aging-related physiological change and predict
health risks among individuals of the same chronological age (CA). Multiple BAs have been …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …

Frailty is a common geriatric syndrome and strongly associated with disability, mortality and
hospitalization. Frailty is commonly measured using the frailty index (FI), based on the …

Estimates from genome-wide association studies (GWAS) represent a combination of the
effect of inherited genetic variation (direct effects), demography (population stratification, …

The epigenome is associated with biological factors, such as disease status, and environmental
factors, such as smoking, alcohol consumption and body mass index. Although there is …

Age-related changes in DNA methylation were observed in cross-sectional studies, but
longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related …

Mitochondrial (MT) dysfunction is a hallmark of aging and has been associated with most
aging-related diseases as well as immunological processes. However, little is known about …