In order to apply human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs)
to regenerative medicine, the cells should be produced under restricted conditions …

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the
potential to provide an infinite source of tissues for regenerative medicine. Although defined …

Anti-p200 pemphigoid has been characterized by autoantibodies to an unidentified 200-kDa
protein (p200) of the dermal−epidermal junction. The objective of this study was to identify …

Recognition of laminin by integrin receptors is central to the epithelial cell adhesion to basement
membrane, but the structural background of this molecular interaction remained elusive…

Laminins are major cell-adhesive proteins in basement membranes that are capable of binding
to integrins. Laminins consist of three chains (α, β, and γ), in which three laminin globular …

Integrin-growth factor receptor cross-talk plays a role in growth factor signaling, but the specifics
are unclear. In a current model, integrins and growth factor receptors independently bind …

Hepatocyte‐like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells
are expected to be applied for regenerative medicine. In this study, we attempted to …

Obtaining highly purified differentiated cells via directed differentiation from human pluripotent
stem cells (hPSCs) is an essential step for their clinical application. Among the various …

Laminins regulate diverse cellular functions through interaction with integrins. Two regions
of laminins—three laminin globular domains of the α chain (LG1–3) and the carboxyl-terminal …

Integrin αvβ3 plays a role in insulin-like growth factor-1 (IGF1) signaling (integrin-IGF1
receptor (IGF1R) cross-talk). The specifics of the cross-talk are, however, unclear. In a current …