Stem-cell ageing is thought to contribute to altered tissue maintenance and repair. Older
humans experience increased bone marrow failure and poorer haematologic tolerance of …

Acute myelogenous leukemia (AML) is the most common adult leukemia, characterized by
the clonal expansion of immature myeloblasts initiating from rare leukemic stem (LS) cells 1 , …

Human acute myeloid leukemia (AML) originates from rare leukemia stem cells (LSCs).
Because these chemotherapy-resistant LSCs are thought to underlie disease relapse, effective …

Cancer stem cells have been proposed to be important for initiation, maintenance and
recurrence of various malignancies, including acute myeloid leukemia (AML) 1 , 2 , 3 . We have …

Whereas humanized mouse models have contributed significantly to human immunology
research, human T cells developing in mouse thymic environment fail to demonstrate HLA-…

A porcine model of severe combined immunodeficiency (SCID) promises to facilitate human
cancer studies, the humanization of tissue for xenotransplantation, and the evaluation of …

Although physiological development of human lymphoid subsets has become well
documented in humanized mice, in vivo development of human myeloid subsets in a …

In recent years, advances in the humanized mouse system have led to significantly increased
levels of human hematopoietic stem cell (HSC) engraftment. The remaining limitations in …

Hematopoiesis in mammals undergoes a developmental shift in location from fetal liver to
bone marrow accompanied by a gradual transition from highly proliferative to deeply …

Leukemia stem cells (LSCs) that survive conventional chemotherapy are thought to contribute
to disease relapse, leading to poor long-term outcomes for patients with acute myeloid …