The biogenesis of exosomes, small secreted vesicles involved in signalling processes, remains
incompletely understood. Here, we report evidence that the syndecan heparan sulphate …

Myotonic dystrophy is the most common muscular dystrophy in adults and the first recognized
example of an RNA-mediated disease. Congenital myotonic dystrophy (CDM1) and …

The PDZ domain is a protein–protein interacting module that plays an important role in the
organization of signaling complexes. The recognition of short intrinsically disordered C-…

The human proteome contains a plethora of short linear motifs (SLiMs) that serve as binding
interfaces for modular protein domains. Such interactions are crucial for signaling and other …

Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host
factors. However, most current large-scale methods do not identify this important class of …

Specific protein–protein interactions are central to all processes that underlie cell physiology.
Numerous studies have together identified hundreds of thousands of human protein–…

The intrinsically disordered regions of eukaryotic proteomes are enriched in short linear
motifs ( SL iMs), which are of crucial relevance for cellular signaling and protein regulation; …

Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules
that perform key regulatory functions and drive dynamic complex formation. For decades, …

It is becoming increasingly clear that eukaryotic cell physiology is largely controlled by
protein–protein interactions involving disordered protein regions, which usually interact with …

The modification of intracellular proteins with O-linked β-N-acetylglucosamine (O-GlcNAc)
moieties is a highly dynamic process that spatiotemporally regulates nearly every important …