A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

Y Yanagi, Y Yoshikai, K Leggett, SP Clark, I Aleksander… - Nature, 1984 - nature.com
We have cloned and sequenced a human mRNA specific for mammalian T-lymphoid cells.
The message was found to be expressed in human and murine T lymphoblasts, thymocytes …

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

…, O Takeuchi, T Kinoshita, S Akira, Y Yoshikai… - Journal of experimental …, 2009 - rupress.org
Tuberculosis remains a fatal disease caused by Mycobacterium tuberculosis, which
contains various unique components that affect the host immune system. Trehalose-6,6′-…

Oncogenesis by retroviruses: old and new paradigms

N Maeda, H Fan, Y Yoshikai - Reviews in medical virology, 2008 - Wiley Online Library
Retroviruses are associated with a variety of diseases including an array of malignancies,
immunodeficiencies and neurological disorders. In particular, studies of oncogenic …

[HTML][HTML] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator

…, H Takayanagi, Y Yokota, H Yamada, Y Yoshikai… - Immunity, 2008 - cell.com
The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs)
express autoimmune regulator and diverse tissue-restricted genes, contributing to …

Resident Vδ1+ γδ T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production

…, H Hara, K Kishihara, Y Yoshikai - The Journal of …, 2007 - journals.aai.org
Neutrophils infiltrate the site of infection and play critical roles in host defense, especially
against extracellular bacteria. In the present study, we found a rapid and transient production of …

Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis

…, N Kaibara, A Hori, Y Iwamoto, Y Yoshikai - Annals of the …, 2008 - ard.bmj.com
Objectives: Recent animal studies have revealed critical roles of interleukin (IL)17, which is
produced by a newly identified subset of helper T cells, Th17 cells, in the development of …

Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice

…, K Ito, T Inokuchi, H Kusaka, H Ikeda, Y Yoshikai - Journal of allergy and …, 1998 - Elsevier
Background: Food allergy is caused by production of IgE against dietary antigen induced by
T H2 response. IL-12 inhibits T H2 responses and strongly suppresses IgE production. We …

Lipoteichoic Acids from Lactobacillus Strains Elicit Strong Tumor Necrosis Factor Alpha-Inducing Activities in Macrophages through Toll-Like Receptor 2

…, K Ishikawa, T Yokokura, Y Yoshikai - Clinical and Vaccine …, 2003 - Am Soc Microbiol
Lactobacilli are nonpathogenic gram-positive inhabitants of microflora. At least some Lactobacillus
strains have been postulated to have health beneficial effects, such as the stimulation …

A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice.

K Hiromatsu, Y Yoshikai, G Matsuzaki, S Ohga… - The Journal of …, 1992 - rupress.org
… In the present study, to elucidate the potential roles of the early-appearing y/~ T cells in the
host-defense against listerial infection, we analyzed the specificity and functions of the 3'/~ T …

Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling

…, T Kikuchi, T Musikacharoen, Y Yoshikai - The Journal of …, 2000 - journals.aai.org
Toll-like receptors (TLRs) are a family of proteins playing important roles in host defense.
Mice defective of functional TLR4 are hyporesponsive to LPS, suggesting that TLR4 is …