Most solid tumors possess unique pathophysiological characteristics that are not observed
in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature, …

Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The
toxic effects of UV from natural sunlight and therapeutic artificial lamps are a major concern for …

The advantages and disadvantages of macromolecular drugs, particularly on synthetic
polymer-protein conjugates, are described in this article. Improvements in protein drugs, after …

A new gene, termed klotho, has been identified that is involved in the suppression of several
ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome …

We previously found that a polymer conjugated to the anticancer protein neocarzinostatin,
named smancs, accumulated more in tumor tissues than did neocarzinostatin. To determine …

We report a simple method, using p53 suppression and nontransforming L-Myc, to generate
human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors. We generated …

Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic
components, serves as a cell survival mechanism in starving cells 1 , 2 . Although altered …

NK911 is a novel supramolecular nanocarrier designed for the enhanced delivery of
doxorubicin (DXR) and is one of the successful polymer micelle systems to exhibit an efficient …

The properties of the bactericidal action of silver zeolite as affected by inorganic salts and
ion chelators were similar to those of silver nitrate. The results suggest that the contact of the …

We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for
doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugated …