User profiles for Wouter Pos

Wouter Pos

PhD
Verified email at vectorytx.com
Cited by 1361

Molecular mechanisms for contribution of MHC molecules to autoimmune diseases

LM Sollid, W Pos, KW Wucherpfennig - Current opinion in immunology, 2014 - Elsevier
… Three amino acid positions in DRβ1 (11, 71 and 74) as well as single-amino acid polymorphisms
in HLA-B (pos. 9) and HLA-DPβ1 (pos. 9) were concluded to almost completely explain …

In vivo discovery of immunotherapy targets in the tumour microenvironment

…, DR Shaffer, DA Alvarez Arias, Y Nakazaki, W Pos… - Nature, 2014 - nature.com
Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable
responses in a subset of cancer patients, despite advanced disease. However, the …

Mechanisms of peptide repertoire selection by HLA-DM

W Pos, DK Sethi, KW Wucherpfennig - Trends in immunology, 2013 - cell.com
Recently, crystal structures of key complexes in antigen presentation have been reported.
HLA-DM functions in antigen presentation by catalyzing dissociation of an invariant chain …

[HTML][HTML] Crystal structure of the HLA-DM–HLA-DR1 complex defines mechanisms for rapid peptide selection

W Pos, DK Sethi, MJ Call, MSED Schulze, AK Anders… - Cell, 2012 - cell.com
HLA-DR molecules bind microbial peptides in an endosomal compartment and present
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …

An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

W Pos, JTB Crawley, R Fijnheer… - Blood, The Journal …, 2010 - ashpublications.org
In the majority of patients with acquired thrombotic thrombocytopenic purpura (TTP), antibodies
are directed toward the spacer domain of ADAMTS13. We have previously shown that …

Binding mode prediction of cytochrome P450 and thymidine kinase protein− ligand complexes by consideration of water and rescoring in automated docking

C De Graaf, P Pospisil, W Pos, G Folkers… - Journal of medicinal …, 2005 - ACS Publications
The popular docking programs AutoDock, FlexX, and GOLD were used to predict binding
modes of ligands in crystallographic complexes including X-ray water molecules or …

[HTML][HTML] Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

W Pos, N Sorvillo, R Fijnheer, HB Feys… - …, 2011 - ncbi.nlm.nih.gov
Wouter Pos, 1 Nicoletta Sorvillo, 1 Rob Fijnheer, 2 Hendrik B. Feys, 3 Paul HP Kaijen, 1
Gestur Vidarsson, 4 and Jan Voorberg 1 … Pos W, Crawley JT, Fijnheer R, Voorberg J …

Amino acid regions 572–579 and 657–666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with …

…, PHP Kaijen, MJ Greuter, W Pos… - Thrombosis and …, 2006 - thieme-connect.com
Antibodies directed against ADAMTS13 have been detected in the majority of patients with
acquired thrombotic thrombocytopenic purpura (TTP). We have previously localized a major …

The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells

N Sorvillo, W Pos, LM van den Berg… - Blood, The Journal …, 2012 - ashpublications.org
ADAMTS13 is a plasma metalloproteinase that regulates platelet adhesion and aggregation
by cleaving ultra-large VWF multimers on the surfaces of endothelial cells. Autoantibodies …

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

…, KT Xenaki, V Neviani, W Pos… - Life Science …, 2020 - life-science-alliance.org
Tetraspanins are eukaryotic membrane proteins that contribute to a variety of signaling
processes by organizing partner-receptor molecules in the plasma membrane. How tetraspanins …