Gene trees record the combination of gene-level events, such as duplication, transfer and
loss (DTL), and species-level events, such as speciation and extinction. Gene tree–species …

Background Nanopore long-read sequencing technology greatly expands the capacity of
long-range, single-molecule DNA-modification detection. A growing number of analytical tools …

Long non-coding RNAs (lncRNAs) represent a class of potent regulators of gene expression
that are found in a wide array of eukaryotes; however, our knowledge about these …

We show that TET2 is required for exit of the GC, B-cell differentiation, and is a tumor suppressor
for mature B cells. Loss of TET2 phenocopies CREBBP somatic mutation. These results …

Background The transcription factor CTCF appears indispensable in defining topologically
associated domain boundaries and maintaining chromatin loop structures within these …

Natural antisense transcripts (NATs) are RNA molecules that originate from opposite DNA
strands of the same genomic locus (cis-NAT) or unlinked genomic loci (trans-NAT). NATs may …

Chromatin interaction studies can reveal how the genome is organized into spatially confined
sub-compartments in the nucleus. However, accurately identifying sub-compartments from …

Bromo- and extra-terminal domain inhibitors (BETi) have exhibited therapeutic activities in
many cancers. However, the mechanisms controlling BETi response and resistance are not …

Here we develop a methylation editing toolbox, Casilio-ME, that enables not only RNA-guided
methylcytosine editing by targeting TET1 to genomic sites, but also by co-delivering TET1 …

Antisense transcription is a widespread phenomenon in mammalian genomes, leading to
production of RNAs molecules referred to as natural antisense transcripts (NATs). NATs apply …