Investigation of contacts of patients with tuberculosis (TB) is a priority for TB control in high-income
countries, and is increasingly being considered in resource-limited settings. This …

During tuberculosis (TB) infection, the granuloma provides the microenvironment in which
antigen‐specific T cells colocate with and activate infected macrophages to inhibit the growth …

The Bacille Calmette–Guérin (BCG) vaccine has been used for more than 80 years to protect
against tuberculosis. Worldwide, over 90% of children are immunized with BCG, making it …

Host immunity to mycobacterial infection is dependent on the activation of T lymphocytes
and their recruitment with monocytes to form granulomas. These discrete foci of activated …

TNF and lymphotoxin-α (LTα) may act at various stages of the host response to Mycobacterium
tuberculosis. To dissect the effects of TNF independent of LTα, we have used C57BL/6 …

The nature of the CD8 + T cells that underlie antiviral protective immunological memory in
vivo is unclear. We have characterized peptide-specific CD8 + T lymphocytes directly ex vivo …

The development of more-effective antituberculosis vaccines would assist in the control of
the global problem of infection withMycobacterium tuberculosis. One recently devised …

Purpose: Therapeutic blockade of immune checkpoints has revolutionized cancer treatment.
Durable responses, however, occur in less than half of those treated, and efforts to improve …

Dendritic cells (DCs) are potent stimulators of immunity, and DCs pulsed with tumor antigen
ex vivo have applications in tumor immunotherapy. However, DCs are a small population of …

Rationale: Genetic variation influences susceptibility to clinical tuberculosis (TB). Activation
of the P2X 7 receptor on human macrophages induces killing of mycobacteria. We have …