Therapeutic efforts to restore biosynthetic processing of the cystic fibrosis transmembrane
conductance regulator lacking the F508 residue (ΔF508CFTR) are hampered by ubiquitin-…

The folding and misfolding mechanism of multidomain proteins remains poorly understood.
Although thermodynamic instability of the first nucleotide-binding domain (NBD1) of ΔF508 …

Coronaviruses are responsible for multiple pandemics and millions of deaths globally,
including the current pandemic of coronavirus disease 2019 (COVID-19). Development of …

The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to
nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to …

Small heat shock proteins (sHsps) bind destabilized proteins during cell stress and disease,
but their physiological functions are less clear. We evaluated the impact of Hsp27, an sHsp …

The O-acetylserine sulfhydrylase (OASS) from Salmonella typhimurium catalyzes a β-replacement
reaction in which the β-acetoxy group of O-acetyl-l-serine (OAS) is replaced by …

Pantothenate kinase (PanK) catalyzes the first step in CoA biosynthesis and there are three
human genes that express four isoforms with highly conserved catalytic core domains. Here …

Overexpression of mitochondria-bound hexokinase II (HKII) in cancer cells plays an
important role in their metabolic reprogramming and protects them against apoptosis, thereby …

The high proliferation rate of tumor cells demands high energy and metabolites that are
sustained by a high glycolytic flux known as the ‘Warburg effect’. The activation and further …

3C-like protease (3CLpro) processes and liberates functional viral proteins essential for the
maturation and infectivity of severe acute respiratory syndrome coronavirus 2, the virus …