The opposing roles of laminin-binding integrins in cancer

V Ramovs, L Te Molder, A Sonnenberg - Matrix Biology, 2017 - Elsevier
Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …

[HTML][HTML] Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

…, A Paulien Drenth, E van der Burg, V Ramovs… - Nature …, 2019 - nature.com
E-cadherin (CDH1) is a master regulator of epithelial cell adherence junctions and a well-established
tumor suppressor in Invasive Lobular Carcinoma (ILC). Intriguingly, somatic …

[HTML][HTML] Integrin α3β1 is a key regulator of several protumorigenic pathways during skin carcinogenesis

V Ramovs, AK Garcia, M Kreft, A Sonnenberg - Journal of Investigative …, 2021 - Elsevier
Integrin α3β1 plays a crucial role in tumor formation in the two-stage chemical carcinogenesis
model (DMBA and TPA treatment). However, the mechanisms whereby the expression of …

[HTML][HTML] Absence of integrin α3β1 promotes the progression of HER2-driven breast cancer in vivo

V Ramovs, P Secades, JY Song, B Thijssen… - Breast Cancer …, 2019 - Springer
Background HER2-driven breast cancer is correlated with poor prognosis, especially during
its later stages. Numerous studies have shown the importance of the integrin α3β1 during …

[PDF][PDF] Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids

V Ramovs, H Janssen, I Fuentes, A Pitaval, W Rachidi… - Stem Cell Reports, 2022 - cell.com
Human induced pluripotent stem cell (hiPSC)-derived hair-bearing skin organoids offer exciting
new possibilities for modeling diseases like epidermolysis bullosa (EB). These inherited …

[HTML][HTML] Generation and genetic repair of two human induced pluripotent cell lines from patients with Epidermolysis Bullosa simplex and dilated cardiomyopathy …

V Ramovs, I Fuentes, C Freund, H Mikkers… - Stem Cell Research, 2021 - Elsevier
Fibroblasts from two patients carrying a heterozygous mutation in the translation initiation
codon (c.2 T > G) of the kelch-like protein 24 (KLHL24) gene were used to generate human …

Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis

V Ramovs, AK Garcia, JY Song, I de Rink… - Life Science …, 2020 - life-science-alliance.org
Epidermal-specific deletion of integrin α3β1 almost completely prevents the formation of
papillomas during 7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (…

Emergence and flight routes of the lesser horseshoe bats Rhinolophus hipposideros (Bechstein, 1800) from a church at Ljubljansko barje, central Slovenia

V Ramovš, S Zidar, M Zagmajster - Natura Sloveniae, 2010 - journals.uni-lj.si
The flight routes from roosts to feeding habitats are important for efficient conservation of
bats, but in Slovenia they are poorly known. Emergence and flight routes of the lesser …

[PDF][PDF] Susana M. Chuva de Sousa Lopes, Christian Freund, Xavier Gidrol, 6 Christine L. Mummery, and Karine Raymond

V Ramovs, H Janssen, I Fuentes, A Pitaval, W Rachidi - repositorio.udd.cl
Human induced pluripotent stem cell (hiPSC)-derived hair-bearing skin organoids offer exciting
new possibilities for modeling diseases like epidermolysis bullosa (EB). These inherited …

[HTML][HTML] Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis

SV Novitskiy, E Forrester, MW Pickup, AE Gorska… - Breast Cancer …, 2014 - Springer
Introduction Transforming growth factor beta (TGFβ) plays a major role in the regulation of
tumor initiation, progression, and metastasis. It is depended on the type II TGFβ receptor (TβRII…