m6A-mRNA methylation regulates cardiac gene expression and cellular growth

…, E Varma, L Jürgensen, V Kamuf-Schenk… - Life science …, 2019 - life-science-alliance.org
Conceptually similar to modifications of DNA, mRNAs undergo chemical modifications, which
can affect their activity, localization, and stability. The most prevalent internal modification …

[HTML][HTML] Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo

…, C Stroh, L Jürgensen, V Kamuf-Schenk… - Basic Research in …, 2023 - Springer
RNA–protein interactions are central to cardiac function, but how activity of individual RNA-binding
protein is regulated through signaling cascades in cardiomyocytes during heart …

Muscle‐specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling

…, J Ölschläger, L Jürgensen, V KamufSchenk… - EMBO …, 2021 - embopress.org
The mechanistic target of rapamycin (mTOR) promotes pathological remodeling in the heart
by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in …

[PDF][PDF] Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes

…, T Schwarzl, T Sekaran, L Jürgensen, V Kamuf-Schenk… - Cell Reports, 2021 - cell.com
RNA-binding proteins (RBPs) control critical aspects of cardiomyocyte function, but the
repertoire of active RBPs in cardiomyocytes during the growth response is largely unknown. We …

[HTML][HTML] PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells

…, A Krull, E Riechert, L Jürgensen, V Kamuf-Schenk… - Scientific Reports, 2019 - nature.com
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory
and atherogenic signals converge upon mechanistic target of rapamycin (…

Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response

…, C Sandmann, L Jürgensen, V Kamuf-Schenk… - bioRxiv, 2022 - biorxiv.org
Rationale Rapid reperfusion is the most effective treatment for attenuating cardiac injury
caused by myocardial ischemia. Yet, reperfusion itself elicits damage to the myocardium …

mTORC1-dependent translational control of Cand2 leads to transcriptional reprogramming in diseased cardiac myocytes

…, V Kmietczyk, L Jürgensen, V Kamuf-Schenk… - Journal of Molecular and …, 2022 - Elsevier
Objectives A cardiomyocyte genome-wide screen approach was used to identify mTOR-dependent
changes in gene expression at the level of mRNA translation that mediates cardiac …

Translational control of the myocardial inflammatory response mediates cardiac ischemia/reperfusion injury

…, C Sandmann, L Jürgensen, V Kamuf-Schenk… - Journal of Molecular and …, 2022 - Elsevier
… Meyer a b , Ellen Malovrh a b , Clara Sandmann a b , Lonny Jürgensen a b , Verena
Kamuf-Schenk a b , Claudia Stroh a b , Hugo Katus a b , Norbert Frey a b , Florian …

Muscle specific translational control of Cand2 by mTORC1 regulates adverse cardiac remodeling

…, E Varma, V Kmietczyk, L Jürgensen, V Kamuf-Schenk… - bioRxiv, 2020 - biorxiv.org
The mechanistic target of rapamycin (mTOR) is a key regulator of pathological remodeling
in the heart by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in …

[CITATION][C] Ythdf2-mediated post-transcriptional control of gene expression regulates cardiac remodeling.

V Kmietczyk, J Ölschläger, V Kamuf-Schenk… - Journal of Molecular and …, 2022 - Elsevier