Regulated cell death pathways have important functions in host defense and tissue
homeostasis. Studies in genetic mouse models provided evidence that cell death could cause …

Historically, Drosophila has been a model organism for studying molecular and developmental
biology leading to many important discoveries in this field. More recently, the fruit fly has …

Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal
bacteria, mucosal immune cells and intestinal epithelial cells (IECs) 1 , 2 , 3 , 4 . Epithelial …

Cell death is intrinsically linked to inflammatory liver disease and cancer development.
Recent genetic studies have suggested that receptor-interacting protein kinase (RIPK)1 is …

Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases
associated with chronic activation of type I interferon (IFN) responses, including Aicardi–Goutières …

Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial
responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-…

Vesicles and other carriers destined for the Golgi apparatus must be guided to the correct
cisternae. Golgins, long coiled-coil proteins that localize to particular Golgi subdomains via …

Ceramides are central intermediates of sphingolipid metabolism with critical functions in cell
organization and survival. They are synthesized on the cytosolic surface of the endoplasmic …

tER sites are specialized cup-shaped ER subdomains characterized by the focused budding
of COPII vesicles. Sec16 has been proposed to be involved in the biogenesis of tER sites …

IκB kinase/nuclear factor κB (IKK/NF-κB) signaling exhibits important yet opposing functions
in hepatocarcinogenesis. Mice lacking NEMO in liver parenchymal cells (LPC) …