Few kinases have been studied as extensively as protein kinase C (PKC), particularly in the
context of cancer. As major cellular targets for the phorbol ester tumor promoters and …

Differentiated thyroid cancer and breast cancer account for a significant portion of endocrine-related
malignancies and predominately affect women. As hormonally responsive tissues, …

Successful tumor eradication by chimeric antigen receptor–expressing (CAR-expressing) T
lymphocytes depends on CAR T cell persistence and effector function. We hypothesized that …

The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective
immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and …

The family of Rho GTPases are involved in the dynamic control of cytoskeleton reorganization
and other fundamental cellular functions, including growth, motility, and survival. Rac1, …

Chimeric antigen receptor–T (CAR-T) cell therapies can eliminate relapsed and refractory
tumors, but the durability of antitumor activity requires in vivo persistence. Differential signaling …

The growth factor heregulin (HRG), a ligand of ErbB3 and ErbB4 receptors, contributes to
breast cancer development and the promotion of metastatic disease, and its expression in …

DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of
single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs. Somatic …

The identification of genomic variants in healthy and diseased individuals continues to
rapidly outpace our ability to functionally annotate these variants. Techniques that both …

Despite our extensive knowledge on the biology of protein kinase C (PKC) and its
involvement in disease, limited success has been attained in the generation of PKC isozyme-specific …