A central aspect of aging research concerns the question of when individuality in lifespan
arises 1 . Here we show that a transient increase in reactive oxygen species (ROS), which …

Small heat shock proteins (sHsp) with a molecular mass of 15-30 kDa are ubiquitous and
conserved. Up to now their function has remained enigmatic. Increased expression under heat …

THE heat-shock protein Hsp90 is the most abundant constitutively expressed stress protein
in the cytosol of eukaryotic cells 1,2 , where it participates in the maturation of other proteins, …

Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise
mechanism (s) of action remains unclear. Here, we show that mesalamine treatment rapidly …

Structural, biochemical, and genetic techniques were applied to investigate the function of
FtsJ, a recently identified heat shock protein. FtsJ is well conserved, from bacteria to humans. …

Thiol-disulfide interconversions play a crucial role in the chemistry of biological systems.
They participate in the major systems that control the cellular redox potential and prevent …

Heterochromatin is most often associated with eukaryotic organisms. Yet, bacteria also contain
areas with densely protein-occupied chromatin that appear to silence gene expression. …

Hsp33, a member of a newly discovered heat shock protein family, was found to be a very
potent molecular chaperone. Hsp33 is distinguished from all other known molecular …

Antimicrobial levels of reactive oxygen species (ROS) are produced by the mammalian host
defense to kill invading bacteria and limit bacterial colonization. One main in vivo target of …

Maintenance of the cellular redox balance is crucial for cell survival. An increase in reactive
oxygen, nitrogen, or chlorine species can lead to oxidative stress conditions, potentially …