User profiles for Umut Sahin

Umut Sahin

Center for Life Sciences & Technologies, Boğaziçi University, Istanbul TR
Verified email at boun.edu.tr
Cited by 2535

Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

U Sahin, O Ferhi, M Jeanne, S Benhenda… - Journal of Cell …, 2014 - rupress.org
The promyelocytic leukemia (PML) protein organizes PML nuclear bodies (NBs), which are
stress-responsive domains where many partner proteins accumulate. Here, we clarify the …

Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

AB Celen, U Sahin - The FEBS journal, 2020 - Wiley Online Library
Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

U Sahin, G Weskamp, K Kelly, HM Zhou… - The Journal of cell …, 2004 - rupress.org
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in
development and disease, are released from the membrane by proteases. In several instances, …

[HTML][HTML] Sumoylation of human argonaute 2 at lysine-402 regulates its stability

U Sahin, P Lapaquette, A Andrieux, G Faure, A Dejean - PloS one, 2014 - journals.plos.org
Gene silencing by small RNAs has emerged as a powerful post-transcriptional regulator of
gene expression, however processes underlying regulation of the small RNA pathway in vivo …

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Z Dassouki, U Sahin, H El Hajj, F Jollivet… - Blood, The Journal …, 2015 - ashpublications.org
The human T-cell lymphotropic virus type I (HTLV-1) Tax transactivator initiates
transformation in adult T-cell leukemia/lymphoma (ATL), a highly aggressive chemotherapy-resistant …

[HTML][HTML] Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication

U Sahin, O Ferhi, X Carnec, A Zamborlini… - Nature …, 2014 - nature.com
Small ubiquitin-related modifier (SUMO) protein conjugation onto target proteins regulates
multiple cellular functions, including defence against pathogens, stemness and senescence. …

[HTML][HTML] Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17

U Sahin, CP Blobel - FEBS letters, 2007 - Elsevier
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in
development and disease, are made as transmembrane precursors. Proteolytic processing by …

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

…, L Ades, O Legrand, R Hleihel, U Sahin… - Blood, The Journal …, 2015 - ashpublications.org
Nucleophosmin-1 (NPM1) is the most frequently mutated gene in acute myeloid leukemia (AML).
Addition of retinoic acid (RA) to chemotherapy was proposed to improve survival of …

Essential role for ADAM19 in cardiovascular morphogenesis

…, G Weskamp, V Chesneau, U Sahin… - … and cellular biology, 2004 - Taylor & Francis
Congenital heart disease is the most common form of human birth defects, yet much remains
to be learned about its underlying causes. Here we report that mice lacking functional …

PML nuclear bodies: assembly and oxidative stress-sensitive sumoylation

U Sahin, H de Thé, V Lallemand-Breitenbach - Nucleus, 2014 - Taylor & Francis
PML Nuclear Bodies (NBs) have fascinated cell biologists due to their exquisitely dynamic
nature and their involvement in human diseases, notably acute promyelocytic leukemia. NBs, …