[HTML][HTML] Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages

CKY Ng, E Dazert, T Boldanova, M Coto-Llerena… - Nature …, 2022 - nature.com
Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage,
HBV-associated HCCs. Here we present an integrated proteogenomic analysis of HCCs …

Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

…, J Cupovic, P Künzler, T Boldanova… - Life science …, 2020 - life-science-alliance.org
Infectious complications in patients with cirrhosis frequently initiate episodes of decompensation
and substantially contribute to the high mortality. Mechanisms of the underlying …

Circulating cell-free DNA captures the intratumor heterogeneity in multinodular hepatocellular carcinoma

…, A Benjak, J Gallon, MA Meier, T Boldanova… - JCO precision …, 2022 - ascopubs.org
PURPOSE Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, with more
than 40% of patients initially diagnosed with multinodular HCCs. Although circulating cell-…

[HTML][HTML] Response prediction of hepatocellular carcinoma undergoing transcatheter arterial chemoembolization: unlocking the potential of CT texture analysis through …

J Vosshenrich, CJ Zech, T Heye, T Boldanova… - European …, 2021 - Springer
Objectives To investigate if nested multiparametric decision tree models based on tumor
size and CT texture parameters from pre-therapeutic imaging can accurately predict …

[HTML][HTML] Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model

…, J Kuipers, CKY Ng, T Boldanova… - PLoS computational …, 2022 - journals.plos.org
Comprehensive molecular characterization of cancer subtypes is essential for predicting
clinical outcomes and searching for personalized treatments. We present bnClustOmics, a …

[PDF][PDF] miR‐579‐3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3‐Kinase–Protein Kinase B Pathway in Chronically Inflamed …

…, S Uzun, S Piscuoglio, T Boldanova… - Hepatology …, 2022 - Wiley Online Library
Chronic liver inflammation causes continuous liver damage with progressive liver fibrosis and
cirrhosis, which may eventually lead to hepatocellular carcinoma (HCC). Whereas the 10‐…

[HTML][HTML] Computed tomography (CT) and magnetic resonance imaging (MRI) of diffuse liver disease: a multiparametric predictive modelling algorithm can aid …

…, C Zaugg, JE Gehweiler, T Boldanova… - … Imaging in Medicine …, 2022 - ncbi.nlm.nih.gov
Background Liver steatosis is common and tracking disease evolution to steatohepatitis and
cirrhosis is essential for risk stratification and resultant patient management. Consequently, …

[HTML][HTML] Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report

…, J Vosbeck, S Taha-Mehlitz, T Boldanova… - Communications …, 2022 - nature.com
Background Focal nodular hyperplasia (FNH) is typically considered a benign tumor of the
liver without malignant potential. The co-occurrence of FNH and hepatocellular carcinoma (…

[PDF][PDF] Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization

T Boldanova, G Fucile, J Vosshenrich, A Suslov… - Cell Reports …, 2021 - cell.com
Although transarterial chemoembolization (TACE) is the most widely used treatment for
intermediate-stage, unresectable hepatocellular carcinoma (HCC), it is only effective in a subset …

Proteogenomic characterization of hepatocellular carcinoma

CKY Ng, E Dazert, T Boldanova, M Coto-Llerena… - bioRxiv, 2021 - biorxiv.org
We performed a proteogenomic analysis of hepatocellular carcinomas (HCCs) across
clinical stages and etiologies. We identified pathways differentially regulated on the genomic, …