RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

J Lin, S Kumari, C Kim, TM Van, L Wachsmuth… - Nature, 2016 - nature.com
Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation through
kinase-dependent and -independent functions 1 , 2 , 3 , 4 , 5 , 6 , 7 . RIPK1 kinase activity …

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

…, M Zelic, J Roderick, C Kim, TM Van… - The Journal of …, 2014 - journals.aai.org
THL and MAK designed and generated the targeting construct and AP performed the gene
targeting in embryonic stem cells and generated the RIPK1 knock-in mice. FKMC provided …

[HTML][HTML] A user's perspective on GeoMxTM digital spatial profiling

TM Van, CU Blank - Immuno-Oncology Technology, 2019 - Elsevier
Abstract Characterization of spatial protein expression for multiple targets from a single tissue
is difficult to perform, especially due to the limitations of multiplex immunohistochemistry …

[PDF][PDF] NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting RIPK1 kinase activity-mediated hepatocyte apoptosis

…, BK Straub, S Krishna-Subramanian, TM Van… - Cancer cell, 2015 - cell.com
IκB kinase/nuclear factor κB (IKK/NF-κB) signaling exhibits important yet opposing functions
in hepatocarcinogenesis. Mice lacking NEMO in liver parenchymal cells (LPC) …

Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function

…, S Konieczka, M Pradas-Juni, S Brodesser, TM Van… - Nature cell …, 2016 - nature.com
Activation of brown adipose tissue (BAT) controls energy homeostasis in rodents and
humans and has emerged as an innovative strategy for the treatment of obesity and type 2 …

[HTML][HTML] Comprehensive analysis of cutaneous and uveal melanoma liver metastases

EP Hoefsmit, EA Rozeman, TM Van… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background The profound disparity in response to immune checkpoint blockade (ICB) by
cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood. …

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

S Kumari, TM Van, D Preukschat… - Life Science …, 2021 - life-science-alliance.org
Tumor necrosis factor receptor 1 (TNFR1) activates NF-κB–dependent pro-inflammatory gene
expression, but also induces cell death by triggering apoptosis and necroptosis. Inhibition …

[HTML][HTML] Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis

TM Van, A Polykratis, BK Straub… - The Journal of …, 2017 - Am Soc Clin Investig
The mechanisms that regulate cell death and inflammation play an important role in liver
disease and cancer. Receptor-interacting protein kinase 1 (RIPK1) induces apoptosis and …

[HTML][HTML] Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE−/− mice

T Imai, TM Van, M Pasparakis, A Polykratis - Scientific Reports, 2022 - nature.com
The development of atherosclerotic plaques is the result of a chronic inflammatory response
coordinated by stromal and immune cellular components of the vascular wall. While …

The role of RIPK1 signaling in liver injury and cancer

TM Van - 2017 - kups.ub.uni-koeln.de
The serine/threonine kinase receptor-interacting protein kinase (RIPK) 1 with pro-death
kinase-dependent and pro-survival kinase-independent functions has emerged as an important …