User profiles for Tongli Zhang
Tongli ZhangUniversity of Cincinnati Verified email at uc.edu Cited by 1440 |
[HTML][HTML] Two heads are better than one: current landscape of integrating QSP and machine learning: an ISoP QSP SIG white paper by the working group on the …
Quantitative systems pharmacology (QSP) modeling is applied to address essential questions
in drug development, such as the mechanism of action of a therapeutic agent and the …
in drug development, such as the mechanism of action of a therapeutic agent and the …
[PDF][PDF] The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation
Cytokinesis follows separase activation and chromosome segregation. This order is ensured
in budding yeast by the mitotic exit network (MEN), where Cdc14p dephosphorylates key …
in budding yeast by the mitotic exit network (MEN), where Cdc14p dephosphorylates key …
Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis
The transcription factor p53 plays a central role in maintaining genomic integrity. Recent
experiments in MCF7 cells have shown that p53 protein level rises and falls in distinct pulses in …
experiments in MCF7 cells have shown that p53 protein level rises and falls in distinct pulses in …
Cell shape and the microenvironment regulate nuclear translocation of NF‐κB in breast epithelial and tumor cells
Although a great deal is known about the signaling events that promote nuclear translocation
of NF‐κB, how cellular biophysics and the microenvironment might regulate the dynamics …
of NF‐κB, how cellular biophysics and the microenvironment might regulate the dynamics …
[PDF][PDF] Intercellular coupling of the cell cycle and circadian clock in adult stem cell culture
Circadian clock-gated cell division cycles are observed from cyanobacteria to mammals via
intracellular molecular connections between these two oscillators. Here we demonstrate …
intracellular molecular connections between these two oscillators. Here we demonstrate …
[PDF][PDF] A dynamical framework for the all-or-none G1/S transition
The transition from G1 into DNA replication (S phase) is an emergent behavior resulting
from dynamic and complex interactions between cyclin-dependent kinases (Cdks), Cdk …
from dynamic and complex interactions between cyclin-dependent kinases (Cdks), Cdk …
[PDF][PDF] Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death
Multicellular organisms shape development and remove aberrant cells by programmed cell
death ("apoptosis"). Because defective cell death (too little or too much) is implicated in …
death ("apoptosis"). Because defective cell death (too little or too much) is implicated in …
[PDF][PDF] Intrinsic age-dependent changes and cell-cell contacts regulate nephron progenitor lifespan
During fetal development, nephrons of the metanephric kidney form from a mesenchymal
progenitor population that differentiates en masse before or shortly after birth. We explored …
progenitor population that differentiates en masse before or shortly after birth. We explored …
Kinetochore–microtubule error correction is driven by differentially regulated interaction modes
M Kalantzaki, E Kitamura, T Zhang, A Mino… - Nature cell …, 2015 - nature.com
For proper chromosome segregation, sister kinetochores must interact with microtubules
from opposite spindle poles (bi-orientation). To establish bi-orientation, aberrant kinetochore–…
from opposite spindle poles (bi-orientation). To establish bi-orientation, aberrant kinetochore–…
[HTML][HTML] SWAP, SWITCH, and STABILIZE: Mechanisms of Kinetochore–Microtubule Error Correction
For correct chromosome segregation in mitosis, eukaryotic cells must establish chromosome
biorientation where sister kinetochores attach to microtubules extending from opposite …
biorientation where sister kinetochores attach to microtubules extending from opposite …