Reevaluation of the d-Amino Acid Compatibility with the Elongation Event in Translation
T Fujino, Y Goto, H Suga… - Journal of the American …, 2013 - ACS Publications
The compatibility of d-amino acids with peptide elongation during translation has been
examined in several studies. However, some of the studies have reported that d-amino acids are …
examined in several studies. However, some of the studies have reported that d-amino acids are …
Ribosomal synthesis of peptides with multiple β-amino acids
T Fujino, Y Goto, H Suga… - Journal of the American …, 2016 - ACS Publications
The compatibility of β-amino acids with ribosomal translation was studied for decades, but it
has been still unclear whether the ribosome can accept various β-amino acids, and whether …
has been still unclear whether the ribosome can accept various β-amino acids, and whether …
In Vitro Selection of Multiple Libraries Created by Genetic Code Reprogramming To Discover Macrocyclic Peptides That Antagonize VEGFR2 Activity in Living Cells
T Kawakami, T Ishizawa, T Fujino, PC Reid… - ACS chemical …, 2013 - ACS Publications
We report the in vitro selection of thioether-macrocyclized peptides against vascular
endothelial growth factor receptor 2 (VEGFR2) from multiple, highly diverse peptide libraries …
endothelial growth factor receptor 2 (VEGFR2) from multiple, highly diverse peptide libraries …
Large-scale analysis of mRNA sequences localized near the start and amber codons and their impact on the diversity of mRNA display libraries
S Umemoto, T Kondo, T Fujino, G Hayashi… - Nucleic Acids …, 2023 - academic.oup.com
Extremely diverse libraries are essential for effectively selecting functional peptides or proteins,
and mRNA display technology is a powerful tool for generating such libraries with over …
and mRNA display technology is a powerful tool for generating such libraries with over …
An amino acid-swapped genetic code
T Fujino, M Tozaki, H Murakami - ACS Synthetic Biology, 2020 - ACS Publications
Preventing the escape of hazardous genes from genetically modified organisms (GMOs)
into the environment is one of the most important issues in biotechnology research. Various …
into the environment is one of the most important issues in biotechnology research. Various …
Optineurin provides a mitophagy contact site for TBK1 activation
…, R Endo, H Kinefuchi, A Sugihara, T Fujino… - The EMBO …, 2024 - embopress.org
Tank-binding kinase 1 (TBK1) is a Ser/Thr kinase that is involved in many intracellular
processes, such as innate immunity, cell cycle, and apoptosis. TBK1 is also important for …
processes, such as innate immunity, cell cycle, and apoptosis. TBK1 is also important for …
cDNA TRAP display for rapid and stable in vitro selection of antibody-like proteins
T Kondo, M Eguchi, S Kito, T Fujino… - Chemical …, 2021 - pubs.rsc.org
We developed a cDNA TRAP display for the rapid selection of antibody-like proteins in various
conditions. By modifying the original puromycin linker in the TRAP display, a monobody …
conditions. By modifying the original puromycin linker in the TRAP display, a monobody …
Exploring the Minimal RNA Substrate of Flexizymes
T Fujino, T Kondo, H Suga, H Murakami - ChemBioChem, 2019 - Wiley Online Library
Flexizymes are tRNA acylation ribozymes that have been successfully used to facilitate genetic
code reprogramming. They are capable of charging acid substrates onto various tRNAs …
code reprogramming. They are capable of charging acid substrates onto various tRNAs …
Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern
…, K Matsuoka, S Umemoto, T Fujino… - Life Science …, 2022 - life-science-alliance.org
Neutralizing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
are useful for patients’ treatment of the coronavirus disease 2019 (COVID-19). We …
are useful for patients’ treatment of the coronavirus disease 2019 (COVID-19). We …
In Vitro Selection Combined with Ribosomal Translation Containing Non‐proteinogenic Amino Acids
T Fujino, H Murakami - The Chemical Record, 2016 - Wiley Online Library
The potential applications of non‐proteinogenic amino acids have increased continuously
since the introduction of these molecules into a ribosomal translation system. An increasing …
since the introduction of these molecules into a ribosomal translation system. An increasing …