Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides
when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within …

Precursors of α-defensin peptides require activation for bactericidal activity. In mouse small
intestine, matrilysin colocalized with α-defensins (cryptdins) in Paneth cell granules, and in …

Paneth cells in small intestine crypts secrete microbicidal α-defensins, termed cryptdins, as
components of enteric innate immunity. The bactericidal activity of cryptdins requires …

Mouse Paneth cell α-defensins, termed cryptdins, are secreted into the intestinal lumen, have
microbicidal activity, and contribute to intestinal innate immunity. Among them, cryptdin-4 (…

Paneth cells at the base of small intestinal crypts secrete granules containing α-defensins in
response to bacteria and maintain the intestinal environment by clearing enteric pathogens …

Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin.
In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth …

Allogeneic hematopoietic stem cell transplantation (SCT) is a curative therapy for various
hematologic disorders. Graft-versus-host disease (GVHD) and infections are the major …

Background & Aims: Recently, the glucocorticoid receptor β (hGRβ) was suggested to play
a role as a dominant negative regulator for determining glucocorticoid response. The aim of …

Chromophore-assisted light inactivation (CALI) is a powerful technique for acute perturbation
of biomolecules in a spatio-temporally defined manner in living specimen with reactive …

The intestinal epithelium is the largest surface area that is exposed to various pathogens in
the environment, however, in contrast to the colon the number of bacteria that colonize the …