Meta-analyses of population-based genome-wide association studies (GWAS) in adults
have recently led to the detection of new genetic loci for obesity. Here we aimed to discover …

Mitochondria are functionally specialized in different tissues, and a detailed understanding of
this specialization is important to elucidate mitochondrial involvement in normal physiology …

Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled nonshivering
thermogenesis in brown adipocytes. This process combusts stored and nutrient energy as …

The molecular mediator and functional significance of meal-associated brown fat (BAT)
thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-…

We compared maximal cold-induced heat production (HPmax) and cold limits between
warm (WA; 27C), moderate cold (MCA; 18C), or cold acclimated (CA; 5C) wild-type and …

Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT).
However, in postprandial state the thermogenic activity and the metabolism of non-esterified …

Thermogenesis in brown adipocytes, conferred by mitochondrial uncoupling protein 1 (
UCP 1), is receiving great attention because metabolically active brown adipose tissue may …

Metabolism is a fundamental process of life. However, non-invasive measurement of local
tissue metabolism is limited today by a deficiency in adequate tools for in vivo observations. …

Lipoic acid is an essential enzyme cofactor in central metabolic pathways. Due to its claimed
antioxidant properties, racemic (R/S)-lipoic acid is used as a food supplement but is also …

Objective Classical ATP-independent non-shivering thermogenesis enabled by uncoupling
protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in …