Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

…, J Stuckey, PV Thomas, T Tittley… - Nature structural & …, 2015 - nature.com
As the sole viral antigen on the HIV-1–virion surface, trimeric Env is a focus of vaccine efforts.
Here we present the structure of the ligand-free HIV-1–Env trimer, fix its conformation and …

An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65

…, T Liu, E Galvan, F Gomez, T Tittley… - Life Science …, 2023 - life-science-alliance.org
RPE65 retinol isomerase is an indispensable player in the visual cycle between the
vertebrate retina and RPE. Although membrane association is critical for RPE65 function, its …

Core Temperature Lability Predicts Sympathetic Interruption and Cognitive Performance during Heat Exposure in Persons with Spinal Cord Injuries

…, C Barton, ML Graham, PP Leung, TD Tittley… - Journal of …, 2021 - liebertpub.com
Among persons with high spinal cord injury (Hi-SCI: > T5), changes in core body temperature
(Tcore) and cognitive performance during heat exposure appear related to degree of …

[PDF][PDF] PD31-10 DEMOGRAPHICS AND MANAGEMENT COSTS OF VHL PATIENTS WITH A PHEOCHROMOCYTOMA: A NATIONAL INPATIENT SERVICE …

…, O Olufajo, A Jain, I Okereke, I Qadir, T Tittley… - The Journal of …, 2020 - researchgate.net
RESULTS: There were 33,535 admissions of patients with a pheochromocytoma who had
an adrenalectomy, with 243 [0.7%] also having the diagnosis of VHL. VHL patients on …

[PDF][PDF] PD31-12 A COMPARISON OF INPATIENT ADMISSIONS FOR PHEOCHROMOCYTOMA IN MULTIPLE ENDOCRINE NEOPLASIA SYNDROME: A NATIONAL …

…, O Olufajo, A Jain, I Okereke, I Qadir, T Tittley… - The Journal of …, 2020 - academia.edu
RESULTS: There were 33,535 admissions of patients with a pheochromocytoma who had
an adrenalectomy, with 243 [0.7%] also having the diagnosis of VHL. VHL patients on …

Heat Exposure Improves Cognitive Performance in Persons with Higher Levels of Spinal Cord Injury

JP Handrakis, TD Tittley, OF Tascione, J Bart… - The FASEB …, 2017 - Wiley Online Library
Our previous work demonstrated that core body temperature (Tcore) is typically lower in
persons with tetraplegia and that limited exposure to cool temperature results in a decline in …

Acute Heat Exposure Results in an Appropriate Initial Decrease in Core Body Temperature in Subjects with Higher Levels of Spinal Cord Injury, but the Thermal …

NS Kumar, M Graham, P Leung, TD Tittley… - The FASEB …, 2018 - Wiley Online Library
Study Objective To determine the initial (30 minutes) and more prolonged (60 & 90 minutes)
response to heat exposure in individuals with higher levels of spinal cord injury (Hi‐SCI; ≥…

PD31-09 PARTIAL ADRENALECTOMY VERSUS TOTAL ADRENALECTOMY IN THE TREATMENT OF PHEOCHROMOCYTOMA IN PATIENTS WITH VON HIPPEL …

…, O Olufajo, A Jain, I Okereke, I Qadir, T Tittley… - The Journal of …, 2020 - auajournals.org
INTRODUCTION AND OBJECTIVE: Pheochromocytomas are functional tumors of the
adrenal gland, that have an incidence rate of approximately 20% in patients with Von Hippel …

PD31-08 DEVELOPMENT OF AN EVIDENCE-BASED POSTOPERATIVE SURVEILLANCE GUIDELINE FOR PATIENTS WITH PHEOCHROMOCYTOMA

R Kumar, P Violette, C Tran, E Tomiak, J Izard… - Journal of …, 2020 - journals.lww.com
METHODS: A guideline committee of urologists, a geneticist, and an endocrinologist was
created. PubMed, Medline, and the Cochrane Library databases were used for evidence …

Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design

AA Ojewole - 2018 - search.proquest.com
Proteins are essential for myriad biological functions, including DNA replication, molecular
transport, catalysis, and antigen recognition. Protein function is determined by three …