User profiles for Tim Hamerly

Timothy Hamerly

GlaxoSmithKline
Verified email at gsk.com
Cited by 493

Critical size limit of biodegradable nanoparticles for enhanced lymph node trafficking and paracortex penetration

GP Howard, G Verma, X Ke, WM Thayer, T Hamerly… - Nano research, 2019 - Springer
Lymph node (LN) targeting through interstitial drainage of nanoparticles (NPs) is an attractive
strategy to stimulate a potent immune response, as LNs are the primary site for lymphocyte …

Conceptual model of biofilm antibiotic tolerance that integrates phenomena of diffusion, metabolism, gene expression, and physiology

PS Stewart, B White, L Boegli, T Hamerly… - Journal of …, 2019 - Am Soc Microbiol
Transcriptomic, metabolomic, physiological, and computational modeling approaches were
integrated to gain insight into the mechanisms of antibiotic tolerance in an in vitro biofilm …

Leishmania-infected macrophages release extracellular vesicles that can promote lesion development

A Gioseffi, T Hamerly, K Van, N Zhang… - Life science …, 2020 - life-science-alliance.org
Leishmania donovani infection of macrophages results in quantitative and qualitative changes
in the protein profile of extracellular vesicles (EVs) released by the infected host cells. We …

A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir

D Tao, B McGill, T Hamerly, T Kobayashi… - Science translational …, 2019 - science.org
A large proportion of ongoing malaria parasite transmission is attributed to low-density subclinical
infections not readily detected by available rapid diagnostic tests (RDTs) or microscopy…

Candidate mediators of chondrocyte mechanotransduction via targeted and untargeted metabolomic measurements

…, DL Zignego, BK Hwang, JK Hilmer, T Hamerly… - Archives of biochemistry …, 2014 - Elsevier
Chondrocyte mechanotransduction is the process by which cartilage cells transduce mechanical
loads into biochemical and biological signals. Previous studies have identified several …

Untargeted metabolomics studies employing NMR and LC–MS reveal metabolic coupling between Nanoarcheum equitans and its archaeal host Ignicoccus hospitalis

T Hamerly, BP Tripet, M Tigges, RJ Giannone, L Wurch… - Metabolomics, 2015 - Springer
Interspecies interactions are the basis of microbial community formation and infectious
diseases. Systems biology enables the construction of complex models describing such …

[HTML][HTML] Characterization of Fatty Acids in Crenarchaeota by GC-MS and NMR

T Hamerly, B Tripet, L Wurch, RL Hettich, M Podar… - Archaea, 2015 - hindawi.com
Lipids composed of condensed isoprenyl units connected to glycerol backbones by ether
linkages are a distinguishing feature of Archaea. Data suggesting that fatty acids with linear …

[HTML][HTML] The Selection of a Hepatocyte Cell Line Susceptible to Plasmodium falciparum Sporozoite Invasion That Is Associated With Expression of Glypican-3

RE Tweedell, D Tao, T Hamerly, TM Robinson… - Frontiers in …, 2019 - frontiersin.org
In vitro studies of liver stage (LS) development of the human malaria parasite Plasmodium
falciparum are technically challenging; therefore, fundamental questions about hepatocyte …

Differences in amino acid catabolism by gut microbes with/without prebiotics inclusion in GDDY-based diet affect feed utilization in rainbow trout

…, CJ Yeoman, TG Gaylord, GC Duff, T Hamerly… - Aquaculture, 2018 - Elsevier
There is the need to enhance feed efficiency and growth of rainbow trout to reduce production
costs of cultured fish. This study conducted a 3 × 4 factorial experiment with three graded …

[HTML][HTML] Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism

…, H Coatsworth, I Mahmud, T Hamerly… - Frontiers in …, 2023 - frontiersin.org
Introduction SARS-CoV-2 subverts host cell processes to facilitate rapid replication and
dissemination, and this leads to pathological inflammation. Methods We used niclosamide (NIC), …