Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions

…, B Steigenberger, T Schäfer, IB Schäfer… - Genes & …, 2023 - genesdev.cshlp.org
Messenger RNAs (mRNAs) are at the center of the central dogma of molecular biology. In
eukaryotic cells, these long ribonucleic acid polymers do not exist as naked transcripts; rather, …

[PDF][PDF] Interconversion between anticipatory and active GID E3 ubiquitin ligase conformations via metabolically driven substrate receptor assembly

…, V Beier, S von Gronau, D Bollschweiler, T Schäfer… - Molecular cell, 2020 - cell.com
Cells respond to environmental changes by toggling metabolic pathways, preparing for
homeostasis, and anticipating future stresses. For example, in Saccharomyces cerevisiae, …

Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies

JH Lee, D Bollschweiler, T Schäfer, R Huber - Science Advances, 2021 - science.org
The chromatin-modifying histone deacetylases (HDACs) remove acetyl groups from acetyl-lysine
residues in histone amino-terminal tails, thereby mediating transcriptional repression. …

[HTML][HTML] 3-D analysis of dictyosomes and multivesicular bodies in the green alga Micrasterias denticulata by FIB/SEM tomography

G Wanner, T Schäfer, U Lütz-Meindl - Journal of Structural Biology, 2013 - Elsevier
In the present study we employ FIB/SEM tomography for analyzing 3-D architecture of
dictyosomes and formation of multivesicular bodies (MVB) in high pressure frozen and cryo-…

Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity

I Riera-Tur, T Schäfer, D Hornburg… - Life science …, 2022 - life-science-alliance.org
The autophagy-lysosomal pathway is impaired in many neurodegenerative diseases
characterized by protein aggregation, but the link between aggregation and lysosomal dysfunction …

Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

…, L Babl, JH Krohn, M Sobrinos-Sanguino, T Schäfer… - Biorxiv, 2023 - biorxiv.org
In most bacteria, division depends on a cytoskeletal structure, the Z ring, which serves as a
scaffold for recruiting additional proteins, with which it forms the machinery responsible for …

Auditory masking of multiple tones by random noise

TH Schafer, RS Gales - The Journal of the Acoustical Society of …, 1949 - pubs.aip.org
One, two, four, and eight simple tones were presented to listeners against a background of
thermal noise. The masked thresholds for the single tones and the various combinations were …

Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

I Riera-Tur, T Schäfer, D Hornburg, A Mishra… - bioRxiv, 2019 - biorxiv.org
The autophagy-lysosomal pathway is impaired in many neurodegenerative diseases
characterized by protein aggregation, but the link between aggregation and lysosomal dysfunction …

Influence of the preceding item in measurements of the noise-masked thresh-old by a modified constant method.

TH Schafer - Journal of Experimental Psychology, 1950 - psycnet.apa.org
" The entire psychometric function for three-sec. tonal signals presented at five-sec. intervals
in a background of thermal noise varies with the intensity of the preceding signal…. Within …

Musical Instruments in Nineteen‐Tone Equal Temperament

TH Schafer, WA Piehl - The Journal of the Acoustical Society of …, 1947 - pubs.aip.org
41. Music as an Aid to Healing: Progress Report. RC LEWIS, War Department Special Staff,
WaShington, DC, HAI• OL•) BmU• IS-MEYEI•, Stevens Institute of Technology, New York, …