Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Signal transduction within the canonical Wnt/β-catenin pathway drives development and
carcinogenesis through programmed or unprogrammed changes in gene transcription. …

Adenovirus E1A proteins prepare the host cell for viral replication, stimulating cell cycling and
viral transcription through interactions with critical cellular regulatory proteins such as RB 1 …

Mediator occupies a central role in RNA polymerase II transcription as a sensor, integrator,
and processor of regulatory signals that converge on protein-coding gene promoters. …

Mutational inactivation of BRCA1 confers a cumulative lifetime risk of breast and ovarian
cancers. However, the underlying basis for the tissue-restricted tumor-suppressive properties of …

BRCA1 has been implicated in the transcriptional regulation of DNA damage–inducible
genes that function in cell cycle arrest. To explore the mechanistic basis for this regulation, a …

Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12
occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of …

Mediator is a conserved multi-subunit signal processor through which regulatory informatiosn
conveyed by gene-specific transcription factors is transduced to RNA Polymerase II (Pol II). …

The physiological and pathological manifestations of Sonic hedgehog (Shh) signaling arise
from the specification of unique transcriptional programs dependent upon key nuclear …

BRCA1 and BRCA2 are breast cancer susceptibility genes. Mutations within BRCA1 and
BRCA1 are responsible for most familial breast cancer cases. Targeted deletion of Brca1 or …