Cyclin-dependent kinase 5 (CDK5) is a unique CDK, the activity of which can be detected in
postmitotic neurons. To date, CDK5 purified from mammalian brains has always been …

One of the most powerful techniques for attributing functions to genes in uni- and multicellular
organisms is comprehensive analysis of mutant traits. In this study, systematic and …

α-Synuclein is a major constituent of pathological intracellular inclusion bodies, a common
feature of several neurodegenerative diseases. Two missense mutations in the α-synuclein …

The microtubule-associated protein Tau is a major component of the neurofibrillary tangles
that serve as a neuropathological hallmark of Alzheimer's disease. Tau is a substrate for …

It has been thought that clathrin-mediated endocytosis is regulated by phosphorylation and
dephosphorylation of many endocytic proteins, including amphiphysin I and dynamin I. Here, …

Hyperphosphorylated tau is a major component of neurofibrillary tangles, one of the hallmarks
of Alzheimer's disease. CDK5 is a kinase that phosphorylates the tau protein, and its …

Cdk5 is a member of the cyclin‐dependent kinases (Cdks), activated by the neuron‐specific
activator p39 or p35. The activators also determine the cytoplasmic distribution of active …

Glycogen synthase kinase 3β (GSK3β) is a multifunctional protein kinase involved in many
cellular activities including development, differentiation and diseases. GSK3β is thought to be …

Background Tissue factor (TF) is a low molecular weight glycoprotein that initiates the
clotting cascade and is considered to be a major regulator of coagulation, hemostasis, and …

To study the global regulation of cell morphology, a number of groups have recently reported
genome‐wide screening data for yeast mutants with abnormal morphology. Despite the …