Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase

T Bashir, NV Dorrello, V Amador, D Guardavaccaro… - Nature, 2004 - nature.com
Skp2 and its cofactor Cks1 are the substrate-targeting subunits of the SCF Skp2–Cks1 (Skp1/Cul1/F-box
protein) ubiquitin ligase complex that regulates entry into S phase by inducing …

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

…, A De Bondt, I Van den Wyngaert, T Bashir… - Bioscience …, 2015 - portlandpress.com
Maternal embryonic leucine zipper kinase (MELK), a serine/threonine protein kinase, has
oncogenic properties and is overexpressed in many cancer cells. The oncogenic function of …

Cyclin A activates the DNA polymerase δ-dependent elongation machinery in vitro: A parvovirus DNA replication model

T Bashir, R Hörlein, J Rommelaere… - Proceedings of the …, 2000 - National Acad Sciences
Replication of the single-stranded linear DNA genome of parvovirus minute virus of mice (MVM)
starts with complementary strand synthesis from the 3′-terminal snap-back telomere, …

In vivo accumulation of cyclin A and cellular replication factors in autonomous parvovirus minute virus of mice-associated replication bodies

T Bashir, J Rommelaere, C Cziepluch - Journal of virology, 2001 - Am Soc Microbiol
Autonomous parvovirus minute virus of mice (MVM) DNA replication is strictly dependent on
cellular factors expressed during the S phase of the cell cycle. Here we report that MVM …

Cdk1: the dominant sibling of Cdk2

T Bashir, M Pagano - Nature cell biology, 2005 - nature.com
Cdk2 is thought to regulate entry into S phase, whereas Cdk1 controls the initiation of mitosis.
New evidence shows that Cdk1 is equally capable of promoting the G1/S transition in …

Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation

S Kitajima, Y Kudo, I Ogawa, T Bashir… - The American journal of …, 2004 - Elsevier
Down-regulation of p27 is frequently observed in various cancers due to an enhancement of
its degradation. Skp2 is required for the ubiquitination and consequent degradation of p27 …

Aberrant ubiquitin-mediatedproteolysis of cell cycle regulatory proteins and oncogenesis

T Bashir, M Pagano - Advances in cancer research, 2003 - Elsevier
The ubiquitin pathway plays a central role in the regulation of cell growth and cell proliferation
by controlling the abundance of key cell cycle proteins. Increasing evidence indicates that …

Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts

C Chargari, C Leteur, E Angevin, T Bashir… - Cancer letters, 2011 - Elsevier
Serdemetan (JNJ-26854165) is a novel tryptamine compound with antiproliferative activity in
various p53 wild-type (WT) tumor cell lines. We investigated its potential as radiosensitizer …

Don't Skip the G1 Phase: How APC/CCdh1 Keeps SCFSKP2 in Check

T Bashir, M Pagano - Cell Cycle, 2004 - Taylor & Francis
By keeping the levels of Skp2 and Cks1 low during G1 progression, APC/C Cdh1 prevents
unscheduled degradation of SCF Skp2 substrates and premature entry into S phase. Thus, …

The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1

…, CC Bjorklund, I Kuiatse, AT Remaley, T Bashir… - … of Pharmacology and …, 2013 - ASPET
JNJ-26854165 (serdemetan) has previously been reported to inhibit the function of the E3
ligase human double minute 2, and we initially sought to characterize its activity in models of …