Progress in the field of mycobacterial research has been hindered by the inability to readily
generate defined mutant strains of the slow-growing mycobacteria to investigate the function …

Two-component regulatory signal transduction systems are widely distributed among bacteria
and enable the organisms to make coordinated changes in gene expression in response …

Introduction: Tuberculosis is the leading cause of death from infectious disease. Current
drug therapy requires a combination of antibiotics taken over >6 months. An urgent need for …

Attempts to construct Mycobacterium tuberculosis strains with a defect in the common aromatic
amino acid biosynthesis pathway were made. In other bacteria the genes of this pathway (…

Background Mycobacterium tuberculosis, the causative agent of tuberculosis, still represents
a major public health threat in many countries. Bioluminescence, the production of light by …

Auxotrophic mutants of Mycobacterium tuberculosis have been proposed as new vaccine
candidates. We have analyzed the virulence and vaccine potential of M. tuberculosis strains …

Identification of new drug targets is vital for the advancement of drug discovery against
Mycobacterium tuberculosis , especially given the increase of resistance worldwide to first- and …

Mycobacterium tuberculosis is able to persist in the human host for decades in an apparently
dormant state where it is presumed to reside in an hypoxic environment. This can be …

The publication of the complete genome sequence for Mycobacterium tuberculosis H37Rv
in 1998 has had a great impact on the research community. Nonetheless, it is suspected that …

The mycobacteria continue to be a genus of great interest and importance, largely due to
the presence of pathogenic species. Mycobacterium tuberculosis, causing tuberculosis, …